Adenylate-forming reductase, a natural product biosynthesis enzyme that resembles non-ribosomal peptide synthetases, yet serves to modify one substrate, rather than to condense two or more building blocks. The A-domain preferentially accepts L-serine, L-alanine and L-valine as substrates. The natural product of the enzyme is not yet known.

Belongs to the adenylate-forming reductase family.

1026 amino acids

MGSDLLSHLSANDRALFWEYGQGAKAFVPFQCAHHAFEFHAKANPDLTAVEEFETKITYKELDRQANCLATRLRGSGVNVGSRVCLLVERSPWLVIGVLGVLKAGAAYIPFDGNVVSDSTLKHAIQDSAPTVILTLRKFQHRVADAASTEIVYLDETLCTSYNPNHCTKPRDFTSSTNSVYIIYTSGTTGTPKGVNVTHGNVTNLLCIAPGNLGMKPGIKVSQMLNISFDFAAWEILGSMVNGATLCLRGKTSKEWKAVMRNVDILFSTPSMLAPHNPADYPNLSTVVVAGEACPKATADLWGARVKFYNACGPTEVTIANTMQLHTPGDIVTIGGPTPNNSVYVLDENMRPVPIGEPGVMWGGGAGITKGYLNLPDKTAERYVPDPFADDGSMMFNTGDLGRWHSNGTLVHLGRIDNQVKIKGFRVELDGVATAMETCPGVQAATALLIDGELWGFATPASLKPEDIKEAALKVQPYYAVPTRYLTLDEFPETANGKTDKRILRQMALDAKNQEEKPANKAPAQNAAWVNLPTTVIAQAAGAQPPTIPHRSSERSLVSTVGSTVVGSQVKQVDSSASSALEKEEYIWSGYLEDEVPEKTQGRIVRNLRHQIFNLYRRLFSVVFIINMALFIWILVTKDYDAHRLGGIVVANVFIGVLMRQEMVINTLFIIFTAVPPSWPLCIRRVCARIYTIGGIHSGAGVSAFVWLVAFTAQATKEMINKGKTSVRTVAITYVILAELLGILIFAYPALRKKMHDTFENTHRYLGWTALALVWIQFMFLTIDYLPEGQTLGQTLVKSPHFWLVIIFTISIIWPWFRLRKVDCRPEVLSNHAVRLWFDYGVTPDAGTFVRLSDAPLKEWHGFASISIPGRTGYSVVVSRAGDWTSKHINDPPTKMWVKGVPTYGVLKLVPMFRRMVLVATGSGIGPCAPAILRRQIPMRVLWTAPNVRETFGDNLCNSILEACPDAVIYDTRKHGKPDMVKLVLRLVKEFDAEAVAIISNQPLTEKVVYGCMSRGIPAFGAIWDS

112.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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