Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. Has no activity with adenosine as a substrate.

Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

364 amino acids

MCPPNTPYQSQWHAFLHSLPKCEHHVHLEGCLEPPLIFSMARKNNVSLPSPSSNPAYTSVETLSKRYGHFSSLDDFLSFYFIGMTVLKTQSDFAELAWTYFKRAHAEGVHHTEVFFDPQVHMERGLEYRVIVDGYVDGCKRAEKELGISTRLIMCFLKHLPLESAQRLYDTALNEGDLGLDGRNPVIHGLGASSSEVGPPKDLFRPIYLGAKEKSINLTAHAGEEGDASYIAAALDMGATRIDHGIRLGEDPELMERVAREEVLLTVCPVSNLQLKCVKSVAEVPIRKFLDAGVRFSINSDDPAYFGAYILECYCAVQEAFNLSVADWRLIAENGVKGSWIGEERKNELLWRIDECVKRFEGVL

40.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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