Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form.

862 amino acids

MEPVSHQGMPRLSWIDTLYSNFNYGTDGYDAEGNEEHKSSREGSETMPYIDESPTMSPQLSARSQDSVDGVSPTPTEVLLPGGESESDKGLLMRKLVLSGVLASEEIYINQLEALLLPMKPLKATASTSQPVLTLQQINDIFYKIEDIYQMHKDFYDKLCPIVLQFDNKTTVGHLFQKLASQLGVYKAFVDNYKFALETAEKCSQCNVQFFKISEDLKVKGPKDSKEQPQSVTMEALLYKPIDRVTRSTLVLHDLLKHTPTDHPDYPLLQDALRISQNFLSSINEDIDPRRTAVTTPKGEPRQLVKDGFLVELSENSRKLRHLFLFTDLLLCAKLKKTTVGKHQQYDCKWYIPLADLVFPSPEESEPIPQLHATPDHEIEEMKAKISVLKSEIQKERKSNKGSSRTIERLKKKMFEYESWLLLYSPTIPFRIHNKNGKSYFFLLSSDYERSEWREAIQKLQKKDLQALALSPFELQVLTASCFKLRTVHNVPIISHKDDDESPGLYGFLHVIVKSAKGFSHSSNLYCTLEVDSFGYFVSKAKTRVFRDTTEPEWNEEFEIELEGSQCLRILCYEKCYDKSKLNKDNNEIVDKIMGKGQIQLDPQVVQSKNWHDDVIEMNGIKVEFSMKFSSRDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCIEEVEKRGIEEVGIYRISGVATDIQALKASFDANSKDILMMLSDMDINAIAGTLKLYFRELPEPLLTDRLYLAFMEGIALSDPAAKENCMMHLLRSLPDPNLMTFLFLLQHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKGHMNLASDIWSHDVMAQVQVLLYYLQHPPISFSELKRSTLYYSTDV

98.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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