Probable tyrosine protein kinase which plays a role in vulva development, probably by acting as a negative regulator of the let-23/EGFR and let-60/ras pathway. Involved in the negative regulation of germline development (PubMed:14657502).

Belongs to the protein kinase superfamily. Tyr protein kinase family.

1043 amino acids

MREEPTAGTADATLNKLLQAADLSGYESDLRRKLKLRNAADLQYVEEVDLLSVGMSRPEQKRLRKEYTKMFPSGIFGKVKKAFKRAESLDRKTSNSVANQDDNDHHVIPIEKITLCKELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSSFLQEAAIMTRMRHEHVVRLYGVVLDTKKIMLVSELATCGSLLECLHKPALRDSFPVHVLCDYAEQIAMGMSYLELQRLIHRDLAARNVLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECINFLKFTSKSDVWAYGVTIWEMFSYGEMPWKGRSGAQILELVDRKKELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDIVAKFPERRAQSVRAVVDCKDSAADHLHFKKDDLIVVISRSPAQYPDGYYWFGSLRNGKLGLFRPTDTVAHLGSEPPCSNGTIENGFSEKEKGGKKNKKAEKESERERKKLLISEPVGDVRHTCHVGIDGTAFGLLQLDKKAMCPTSSSPSTSRGSQASPAPSHTSSSTTSSVHLRETVARNGVPIKETMSLRDVGPLSRDALNLRDTVSPPVARAPSQPPSYSQPRPPPRSVSSVSSGNQHSVQVHDQFSSLDRSRGSLTPTAPPLTASAANSLKDPLTGISLSIPSNNLISYMDDQEDDHRWTRSPGAISQSTTLTALSSSRKDPIPAPRGPVAAVYARGKDIPTPASKSDIALCEKIEDLNRDLTNYSIGTICDYSEDRPLLDSMNRTISSSTTHQPPPQSSEARIRFMTEQEVRKINEKSAREHRKTEDLLREERQKEQKPGEIEEPQQPAESLYSTRTPQQEGWSSAAQEAYKLLVECGTNLKQASVSPPPMSPTSSRLSTLDRSSISPAPPRPVTPPLSVRNETISMRKSQQEEMEHVTVEENSPKRVHIIETKLIDGPARGMSPIQDRHIPAFTTPMSNGSFRKAPAPTPVSPAPAGSTDQKPPPCRPPKTRQFPLVIDERNLAYDNLNGFGAGARVAPPVPPKPKVRTIFSFADDQKKQKEVAN

115.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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