Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.

Belongs to the acireductone dioxygenase (ARD) family.

180 amino acids

MAVIKVRKTGQVIEGEDNVRAFLNSQGVLYEHWDITKLPEHLRDKYVLTDEEKNEILATFKDEIEDLAARRGYKTWDIVALSDATPNLDELLKKFEQVHIHTEDEVRAITAGHGIFIIKGDKETGYFDVELEAGDVISVPEGNPHYFTLMDDRRVVAVRLFIDPSGWVAHPYEEKEEAVQ

20.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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