Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis (By similarity).

Belongs to the ANP32 family.

263 amino acids

MEMKKRISLELRNRSPAEVAELVLDNCRSVDGEIEGLNDSYKELEFLSMANVELKSLSKLPKLPKLRKLELSDNSISGGLDVLTERCPNITYLNLSGNKIKDLSTVEALASLKNLKSLDLFNCEITNLEDYRENIFQRLSQITYLDGFDQEDNEAPDSEEDDDDDDYDDDEEPGPRRYEAEEDEEDEESASDLGEEEEEEEEVGLSYLMKEEIRDEEDDDDYVEDGAEGEEEEEEDEEDEAAAADQGEKRKRDPEDEGDEDED

30.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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