After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. A subunit of the levamisole-insensitive nicotinic receptor (By similarity).

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.

499 amino acids

MSSVCALLLSCALFLVAHGSLQERRLYEDLMRNYNNLERPVANHSEPVTVHLKVALQQIIDVDEKNQVVYVNAWLDYTWKDYNLVWDQAEYGNITDVRFPAGKIWKPDVLLYNSVDTNFDSTYQTNMIVYSSGLVHWVPPGIFKISCKIDIQWFPFDEQKCFFKFGSWTYDGYKLDLQPATGGFDISEYLPNGEWALPLTTVERNEKFYDCCPEPYPDVHFYLHMRRRTLYYGFNLIMPCILTTLMTLLGFTLPPDAGEKITLQITVLLSICFFLSIVSEMSPPTSEAVPLLGIFFTCCMIVVTASTVFTVYVLNLHYRTPETHDMGPWTRNLLLYWIPWILRMKRPGHNLTYASLPSLFASKPNRHSESLIRNIKDNEHSLSRANSFDADCRLNQYIMTQSVSNGLTSMGSIPSTMISSTNGALTDVSQQATLLILHRIYHELKIVTKRMIEGDKEEQASNNWKFAAMVVDRLCLYVFTIFIIASTIGIFWSAPYLVA

57.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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