Catalyzes the reversible conversion of a variety of acids to the corresponding acyl-CoA esters. Shows the highest activity with the aryl acids, indoleacetate and phenylacetate, as compared to acetate. In the reverse direction, phenylacetyl-CoA is the best substrate. Seems to be involved primarily in the degradation of aryl-CoA esters to the corresponding acids. Participates in the degradation of branched-chain amino acids via branched-chain-acyl-CoA esters.

In the C-terminal section; belongs to the acetate CoA ligase alpha subunit family.

673 amino acids

MLLLEHESKALLEKYGIKTAKCIFCETEEQAVKAAKEIGFPVVMKVAGREIVHKSDVGGVILNVKSEDEVREVFQRLMSIPKAEGVNIQPQLEKGIEVIVGVAENEQFGSVAMFGLGGVFVEVLKDVSFRLLPLTRRDAEEMVREVKGYKLLEGYRRVKGDVGAVVDLLLKLNEVVERESIVEMDLNPVFVYERGAVVADARIVVGERKRFDYTIPDLRDLFYPKSVAVIGASRTVGKPGFNIVWNLKQNGFMGKIYPVNPNADKILELKCYPSILDIPDEVDMAIIAVPAKIVPEVMAECAQKGIKGAVIVSSGFSEEGEKGAEYERRVLEIAKKHGIRIFGPNTTGVLNTENGFITSFAIQPVIKKGNIGIIAQTGLFLGIMMDIVTSNHPSIGFSKIVGMGNKIDVEDYEVLDFLLKDEQTKVIGIYMEGIKNGRAFYDVASSAEKPIVVFKSGRTEYGQKAAMSHTASICGDDDVFDAVCRQANLVRVYSFDELFDVTKAFSLQPLPKGDRVAIIHYTGSGCVQGSDAAYFAGLKLAEFSKDTVDKISEVTPEWHNVNNPIDIWPMVEYYGAFKAYQTAIEAVMEDEGVDSVIACVWANRLINADFEPDYKSLKKYGKPIYFCVEGARDVVFDHKNALELNGIPVYTNVINAVNVLGKVTKYAKRRIQS

74.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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