Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in somatic and germ cells (PubMed:10749938, PubMed:12498686, PubMed:11134076, PubMed:17237515). Required for embryonic anterior-posterior axis formation (PubMed:11832245). Negatively regulates ify-1 protein levels during meiosis I (PubMed:12498686). Plays a role in regulating the abundance of glr-1 receptors in postmitotic neurons, which may in turn control animal locomotion (PubMed:15556870). Involved in regulating GABA neurotransmitter release at neuromuscular junctions in GABA motor neurons (PubMed:24321454).

Belongs to the APC4 family.

1027 amino acids

MDFSIVKTQILNNRRTFRTPFKVSSMCFSSQNDLIALGSKTGEILLKRTSWKMIWKTNINMIQAVGTECKLDSSVSALHFSPDGRFLAAATSKGIIHLLDVETGKVRFSVKAASEKIAKLHWNCVREKPFISNLGEFTTRIKNVEAIEGAIELAETTPNISQEEIAFVYQRLDEDGSSFKHEDAHKESLERTLISTETFRESLQNTILLATDDMDSKIIVLVAGVFPYMEIDISDTLLQYNQSLLMLYDMHYSSAFGGVSFLATTYGPFLDCKQNELKPPGAEPKKDGQGCHTLLFNVKLNINSSLWDTALRYIRLLFGFNLYSISLETTKRNWEEQIDNLHSLFDTKTKAVKIGNVLLEMLLSGSTDAAGEAFLERGLGTDGLDKIELFATKHMPEVCRIARGQLSTSARNLCFQRCEFSTSLSRYAKFIQLKDDDSFLYDEDPPAYLSESNIWLNTLEEKINILDMKTRHLGIQCLTMMQELGHLVKWISMTKPFAKTMKVNALMKIKRMNIAKILLYIVRNFIPDPEAVKDIENRLFNLKELVSKQKKKDLEDKFDEVEYLYRLERIAEVERKKLIETFHEKFRFADLDDDDLTPLLFQELDHPIDIFTDSMMEQNDSSPFLEEDEGEPEQEEQKPDEEPEPEGEPQPACDLDRVGSFFEKELSQKALEVLPKCDETFDCVLNERGSRMNSIEIQKMGILRVLEDLAATLSSPQKIHCDKAGNQKKLEVSFIYEITSTPTHQGYQDAKISSVTPSYYKRHPFNQLSGMGRSIQVSVLQKNEFSSIVIVPTSDVLPEDENEVNDHVEKLKRCYEFEKIDVTVDKSSAENRPPGETDAMEVDSNELRIDVDLGPVVPEYDTLIELSQVHPLHHGELVLLGKFTSAQEGTGVMSQMMRSISSYPHEIPEDKDVFAKNSSEDGSSEIPIETLIIHPTIQLAAYLHDDGSKITIGDMKPEVPPIADYEEKTVRKTFRDYQRRRERYREDMGVMNMNDVQYDVLVQEAMDSGRDLTDNGESDEDEEDDDI

117.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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