Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

In the C-terminal section; belongs to the peptidase M41 family.

728 amino acids

MSNEPKSKRGGSSENRGGGNVWLVLLAVTGAVVLSAFLFSDNRRRLAYPHLKELLAMSAERQEMLEAQRSASESGDAAANVDGESRPESSVISRSSSALISGDPANDIPVPKIVVPSSTKEDVWHEFSRLDNIFVADDRITGKVHFKSFVKNHPSEKEPAEEVTFLTIRGYPNDLIAAELEDLLVQSGVKWDNDRPSRFLENHWPELLMIGVLVALGIVMLKRMGGVGSPMSFSRSRGKLYSEDDLPTTFEDVAGIEEAVDEVREVVDFLKNSEKYQSLGGRIPKGVLLVGPPGTGKTLLAKAIAGEAGVPFFSLSGSDFVEMFVGVGAARVRDMFTQAVNRAPCIIFIDELDALGKSRSGSVVGGHDEREQTLNALLVEMDGFDSNSGVIVVAATNRPETLDPALLRPGRFDRHVLVDRPDVAGREEILAVHVKNVKLDETVELKGIASITSGFVGADLANLVNEAALLAARNGKPAVAMEEFNEAVERVTAGLEKKNRVMNEDEKIRVAYHESGHALVAAALPNTDPVHKVSIIPRGLAALGYMMQRPESERFLMTKSELESQMKVMLAGTLAEEMIFQDISTGAQNDLERCTETARSMVMDYGMSRLGRINLRRNTRSPFLAGSGGGEYQIMHSDEMAKMIDKEVSRIVDDMLVHTREILEQRRDVLEAVTQRLLEVEAIDSDELMRLIQENSRGPWLVPGTVTEKPKAKIVPREETESQQSNRS

79.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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