ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.

Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.

654 amino acids

MAPTQPQTKVRKPPRSWDALTPPLAQWILDYLSSMGFTQPTPVQKSCLELFRGNKDVVVEAVTGSGKTLAFLIPVVEKLLRGEEPAKRNHVQGIIISPTRELATQIYNVLVSLVKFHEPSAEAISHAKSDEKRPTATQPVVVPQLLVGGTTKAAEDLGTFLRLSPNLLIGTPGRLAELLSSAYVKAPASTFEVLIMDEADRLLDMGFANELNRILGYLPKQRRTGLFSASLSDAVERLITVGLLYPHKITVRVKSLKDGGIIQERKTPMSLQMSYLVTPASQKMPAIVQLLEKLEPRPQRSIIFFSSCMAVKYFSRILGAVLPAGFSVTSLHGKLEPKVREKNYERFVNTTSPMVLLTTDLAARGLDIPQVDLVIQHDPPTDTKVFIHRCGRAGRAGRRGLAVVLLQPGREEGYVQLLEVRQTPITPLEKPAISVTPDEVERVSAAFRSQALADREIFQMAQLAFVSWTRSYIEHQASSIFRIADLDWLDLAKGYGLLELPKMPEVREAKIDRSLGLGINTEEIPFKDKVREKKRQEELAKWKEEKAKRAQEENTGDKRKKNEAWSGKAEQEETKLQRREKKRRKREAKKFSEMTEKEKEEHLKLEQMIEEVRKRNEAKAAEERAAALAANPPKPKAPVKKVDDSDEEFGGFDD

73.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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