Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Belongs to the NnrD/CARKD family.

353 amino acids

MSSESSTGPEMSATTKQMLARVRQMVPPMLEKFHKGQLGRVAVIGGSEDYTGAPYFSAMASARLGADLSHVICTPNAAQVIKTYSPNLMVHPLMRSSPPALSSSDSGSSPSRTKSAPDTDPSQIAAQIIPMLDRLHVLVIGPGLGRDPLMQETCAKVITAAREKGIPMVLDADALLLVTKDPSLIKGYDNAVLTPNVVEFGRLTKALGVDEEVEKAEETAGETAKVEALAKALGGVMVVQKGAKDYLSDGKVTLTVDLKGGLKRSGGQGDTLTGSIATFLGWRRAYLEDLWDHGHKLNKEELIGLAVFGGSAITRECSRLAFAKKGRSLQASDLTDEVHTAFLNLFGEVDAKL

37.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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