ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity).

Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.

787 amino acids

MAPAAGPRTGKHAKPQRSKTLKRKRGQEELSSLIQRVEDLDLKGIFKSFSDLPLSEPTASGLASSHYKTLTDIQSRAISHALKGRDILGAAKTGSGKTLAFLVPVLENLYRKQWAEHDGLGALILSPTRELAIQIFEVLRKIGRYHTFSAGLVIGGKSLKEEQERLGRMNILVCTPGRMLQHLDQTALFDTYNLQMLVLDEADRILDLGFQQTVDAIIGHLPKERQTLLFSATQTKKVSDLARLSLQDPEYVAVHETASSATPSKLQQHYVITPLPQKLDILWSFIRSNLKSKTMVFLSSGKQVRFVYESFRHLQPGIPLMHLHGRQKQGGRLDIVTRFSQSKHCVLFSTDVAARGLDFPAVDWVIQLDCPEDADTYIHRVGRTARYEREGRAVLFLDPSEEEGMLKRLEQKKVPIEKINIKANKQQSIKDQLQNMCFKDPELKYLGQKAFISYVKSVYIQKDKEIFKLKELKLDEFAASLGLPGAPRIKFIKGDDTKQRKNAPRAAAHLLSDDDDTDEEDGEKKSKKKEEPQVRTKYDRMFERRNQDVLAEHYSKLINDDGTMVAPNAGAGADADEDDDFLSVKRRFDAGDKDLGSSGDEDDESEKGNKKNVKVRREKLLKSKKKLLKFKGKGTKLVYDDEGNPHELYELEDEEQFKARGDAKDQQAKFLAEEAERTRLADMEDKEIAKQKRREKKEKRKARERELLAEAEEEETLVQLPPYEGDQDDEAPRPSKKPKVKFTEANDREEAEPWYKKSKKSSDQAAHTPRQIQTLEDLESLATGLLG

89.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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