ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity).

Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

614 amino acids

MSSTKKHSRSEGEEKDARLAKKVKTDETPVDGEVKKERKKDKKEKKDKKEKKDKKSKKEKKDQDESPATESTEDVSMPDAAAEPVADKKEKKEKKDKKEKKDKKEKKAKKSDESTTEESTSASKATTNGTTTPAASTNGAYTYKQADALSALPESEIETFLKEKEIVIKDPSSSNLRPIMNFSQLPQSNLISKNPFAAYTNPTPIQSASWPFSLSGRDVIGIAETGSGKTMAFSLPCVESLASRPKPKFNSRDRTAHPRAVIVSPTRELAMQTHAALSGLASLVGLSAVCIFGGSDKNEQRNLLYKNNGVDIITATPGRLKDFLSEGSISLANVSFAVLDEADRMLDRGFSEDIKLILSGCPPKEQRQTLMFTATWPLDIQKLAESYMINPAQVTIGHRTRAGGDGEGNGNIELQANSRIEQKVEVVDPRGKEFRLYELLKEAQKGSQKDDRILVFCLYKKEAVRVEQFLSRKGIKVASIHGDLRQDQRTRSLEAFKSGTTTVLVATDVAARGLDIPEVKLVINVTFPLTIEDYVHRIGRTGRAGKLGKAITLFTEHDKAHSGSLVNILRAAKQPVPEELLKFGTTVKKKAHDAYGSFYKDIDPNKKATKITFD

67.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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