ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity).

Belongs to the DEAD box helicase family. DECD subfamily.

442 amino acids

MSHEGEEDLLEYSDNEQEIQVDATNINESAVDATVSETAEGATTDSEKKGSYVGIHSTGFKDFLLKPELARAIIDCGFEHPSEVQQHTIPQSIHGTDVLCQAKSGLGKTAVFVLSTLQQLDPVPGEVSVVVICNARELAYQIRNEYLRFSKYMPDVKTAVFYGGTPITKDAELLKNKETAPHIVVATPGRLKALVRDKLIDLSHVKNFVIDECDKVLEELDMRRDVQDIFRATPRDKQVMMFSATLSEEIRPICRRFLQNPLEIFVDDEAKLTLHGLQQYYIKLQENEKNRKLAQLLDDLEFNQVIIFVKSTKRANELTKLLNESNFPAITVHGNMKQAERIARYKAFKEFEKRICVSTDVFGRGIDIERINLAINYDLTTEADQYLHRVGRAGRFGTKGLAISFVSSPEDEEVLGKIQERFDVKIAEFPEEGIDPSTYLNN

50 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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