ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.

Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.

760 amino acids

MTTDTTKQKRKLDSKQNTSPKRRKVQANGKAQPKAKKPKRVVAADSLSWRSVEIPELFDDAEGFFGLEEVEGVDVIRDGGMVKFVTAAPAAEKEDEGDDFSGFDDNPESTSLVAAEEAKSEEPAKPQSQKKQQTKQPKSETKEKKEKPAKAKKNEKQTSKTDDDDLATGSFAALAEIDETDEGADVSEWEPLGLSEEIMSSIAKLKFAKPTAIQAATIPEILAGHDVVGKASTGSGKTLAFGIPIVEKWLSINASTQSKRVAEGETKTPIALVLSPTRELAHQLTDHIKNLCAGLATSPYVCSVTGGLSVHKQQRQLEKADIVVGTPGRLWEVLSSSTKLIQAFRGIKFLVVDEADRLLSEGHFKDAKDIFEGLDKVETDDDGIIRGGKARQTLVFSATFNKGLQQKLAGKGRFDLATDSQSMEYLLKKLKFREEIPKFIDVNPVSQMAEGLKEGIVECGAMEKDLYLYSLLLMHPTQRTLVFTNSISSVRRLTPMLQQLTLPVIALHSQMIQKARLRSVERFTSSKPGSASILIATDVAARGLDIRGIDVVIHYHVPRTADAYVHRSGRTARADSSGLSILICAPEEVTPTRRLVAKVHASAAAKGKKKGSAGGVFVHSVELDRRLVSKLRERVQLAKQIADSTLAKEKIGKEDNWMQKAAEELGVEYDSEDLEKASNWSGRGSGRKSKQKEAKEMSKAEVASLKAQLKQLLSKRINSGVNERYIANGNVDIDGLLSGAKGDFLGKVEGLGVSPLLATD

82.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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