ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG5 has ATPase activity.

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

694 amino acids

MAEKTKEETQLWNGTVLQDASSLQDSVFSSESDNSLYFTYSGQSNTLEVRDLTYQGGTCLRSWGQEDPHMSLGLSESVDMASQVPWFEQLAQFKLPWRSRGSQDSWDLGIRNLSFKVRSGQMLAIIGSAGCGRATLLDVITGRDHGGKMKSGQIWINGQPSTPQLIQKCVAHVRQQDQLLPNLTVRETLTFIAQMRLPKTFSQAQRDKRVEDVIAELRLRQCANTRVGNTYVRGVSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVRTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGVAQHMVQYFTSIGYPCPRYSNPADFYVDLTSIDRRSKEQEVATMEKARLLAALFLEKVQGFDDFLWKAEAKSLDTGTYAVSQTLTQDTNCGTAAELPGMIQQFTTLIRRQISNDFRDLPTLFIHGAEACLMSLIIGFLYYGHADKPLSFMDMAALLFMIGALIPFNVILDVVSKCHSERSLLYYELEDGLYTAGPYFFAKVLGELPEHCAYVIIYGMPIYWLTNLRPGPELFLLHFMLLWLVVFCCRTMALAASAMLPTFHMSSFCCNALYNSFYLTAGFMINLNNLWIVPAWISKMSFLRWCFSGLMQIQFNGHIYTTQIGNLTFSVPGDAMVTAMDLNSHPLYAIYLIVIGISCGFLSLYYLSLKFIKQKSIQDW

78.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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