Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level (PubMed:19888333). Important during development for the up-regulation of mitochondrial activity during the transition to higher larval stages (PubMed:19888333). Regulates mitochondrial iron homeostasis (PubMed:26427876). May play an important role in mitochondrial protein synthesis (By similarity). May also participate in mitochondrial DNA replication (By similarity). May bind to mitochondrial DNA D-loops and contribute to nucleoid stability (By similarity). Plays a role in regulating the production of reactive oxygen species in response to heat stress (PubMed:22245785).

Belongs to the AAA ATPase family.

595 amino acids

MSWLFGVQKNATPQIPDDFQAGAAPGGPQQPGQGQRQEGNSKMAYSFDSTALERAAKAARDLEKFPNAKEALELSRMQEVTRQKEVENETKKIEAQLANMKSEHIRVAEEERRKTLGEETKHAHSRAEYQDQLARKRAEEELAMKARMQEESLRKQEESVKKQEQLRKQTIEHELALKHKYELEKIDAETRARAKAARDNRDVNLEQMKLHEEENRKTVIEKIKTSGELIGSGLNQFLNDKTKIAAAVGGLTALAVGWYTAKRGTGVTARYIESRLGKPSLVRETSRITPLEVLKHPIKSVQMMTRQKKDPLNGVVLPPALERRLRDIAITTSNTKRNNGLFRNVMFYGPPGTGKTLFAKSLAQHSGLDYAVLTGGDIAPLGRDGVSAIHKVFDWASKSRKGLIVFIDEADAFLQKRSKNGMSEDTRAALNAFLFRTGEQSRKFMLVVASNQPEQFDWAVNDRFDQLVEFTLPGMEERERILLQYFNEHIVTPATSGSRSQRLKLDNFDWVAKCNEVAKKTSGMSGRELSKLVIGWQASAYASETGVLTEAIVDRNTADAMVQHEHKMEWLEKEQLKARNQEVKFGTTLKRETAV

67.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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