Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).

Belongs to the ATP phosphoribosyltransferase family. Short subfamily.

212 amino acids

MTDYITIAIPKGRILEESVTLFGKIGINCDELLSNTRKLIFENHEQRMRYMIVRATDVPTYVEYGCADLGIVGKDTLMEQEKDLYEPLDLKFGYCRMMVAEPAGLALDDDPSSWTNIRIATKYPNVTEKYFARKGVQVEIIKLYGSIELAPLVGLSERIVDLVSTGETLRQNGLVEVETIAEITTRLIVNRASLKTKHPRITEIIEGLEKHV

24 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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