Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting at the trans-Golgi network and early endosomes (TGN/EE). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity).

Belongs to the adaptor complexes large subunit family.

862 amino acids

MNPFSSGTRLSDMIRAIRASKTAAEERAVVRKECAAIRASINENDQDYRHRDLAKLMFIHMLGYPTHFGQMECLKLIASPGFPEKRIGYLGLMLLLDERQEVLMLVTNSLKQDLNHTNQYIVGLALCALGNICSAEMARDLAPEVERLLQFRDPNIRKKAALCAIRIIRKVPDLSENFINPGAALLKEKHHGVLITGVHLCTEICKVSSEALEYFRKKCTEGLVKTLRDIANSPYSPEYDVAGITDPFLHIRLLKLLRVLGQGDADASDCMNDILAQVASKTESNKNAGNAILYECVQTIMSIEENGGLRVLAINILGKFLSNRDNNIRYVALNMLMRSLTVDSQAVQRHRATILECVKDSDASIQKRALELIYLLVNENNVKPLAKELIEYLEVSEQDFKGDLTAKICSIVEKFAPEKIWYIDQMLKVLSEAGTYVKEDVWHALIVVITNAPDLHGYTVRALYRALHTSFEQETLVRVAIWCIGEYADLLVNNAGMLDLEDPITVTESDAVDVVENAIKHHLSDVTTKAMALIALLKISSRFPSCSERVKSIIGQNKGSFVLELQQRSLEFSSVIQKHQNIRSSLVERMPVLDEATFSGRRAGSLPASVSTSGKSPLGIPNGVAKAAAPLVDLLDLGSDDTPAPTSSSNNFLQDLLGVDLSQPSAQPGAMQPSQAGADILMDLLSIGTPAPVQNGSANGDLLSIQDNNAPIAPSLTSPTAPSSMMDLLDGFGPTPPKSEDKSAAYPSIVAFESSSLKIEFNFTKQSENPQTTDIVANFINLTPNVYTEFLFQAAVPKFLQLHLDPASSNSLPANGNIKQTMRVTNSQKGKKPIVMRMRVGYKINGKDVLEEGQINNFPRGL

94.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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