Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin-mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.

257 amino acids

MEFPDLGAHCSEPSCQRLDFLPLKCDACSGIFCADHVAYAHHHCGSAYQKDIQVPVCPLCNVPVPVARGEPPDRAVGEHIDRDCRSDPAQQKRKIFTNKCERSGCRQREMMKLTCDRCGRNFCIKHRHPLDHDCSGEGHPTSRAGLAAISRAQGLASTSTVPSPSRTLPSSSSPSRATPQLPPRTTSPVIALQNGLSEDEALQRALELSLAEAKPQIPSSQEEEDLALAQALSASEAEYQQQQAQSRSLKPSNCSLC

27.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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