Immunity component of an interbacterial competition system (also called effector-immunity systems). Expression in E.coli neutralizes the toxic effects of non-cognate S.proteamaculans effector protein Tre1 (Tre1-Sp); cannot be co-purified with Tre1-Sp from E.coli, suggesting they do not form a stable complex (PubMed:30343895). Probably acts as an arginine mono-ADP-ribosylhydrolase, mediating the removal of mono-ADP-ribose attached to arginine residues on proteins. Probably de-ADP-ribosylates FtsZ and possibly other proteins; the ability to hydrolyze ADP-ribosyl moities is not essential for neutralization of its cognate toxin, strongly suggesting its N-terminal extension occludes the active site of cognate toxin Tre1 (Probable).

Belongs to the ADP-ribosylglycohydrolase family.

371 amino acids

MIDLRSPNALLSDYVERYAHLSPEPSRQLQQRMDYNVRADAPAEPASKPRWLQSRACTLTPEQALDRAKGALLGLAIGDAVGTTLEFLPRDREHVNDMVGGGPFRLAAGEWTDDTSMALCLADTYVSQGKFDYATYANALVRWYRHGENSVNGRCFDIGNATRNALEGWLREGIGWQGNYDPSTAGNGSIIRLAPTAIFRRHSLSASWWESVTQSSVTHNADEAVNCCQLLAAQLHLALNGADKEETLAPAVRSLRPRPMIINAGEYKQKSRDQIRSSGYVVDTLEAALWAVWNSNNFHDAILLAANLADDADSVAATAGQLAGALYGVSGMPPEWVEKVAWSQHIQKLAQELFDRAPQVDELDALLYGKR

40.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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