Catalyzes the prenylation of L-tryptophan at the C-7 position of the indole moiety. The enzyme is specific for dimethylallyl diphosphate (DMAPP) as prenyl donor. Accepts also D-tryptophan, typtophan-derivatives with modifications at the side chain or the indole ring, and linear and cyclic dipeptides such as H-L-Trp-L-Gly-OH or cyclo-L-Trp-L-Gly as substrates, however with lower efficiency. Also has tryptophan aminopeptidase activity towards linear peptides with a tryptophanyl moiety at the N-terminus. Dipeptides are better substrates than peptides with 3 or more amino acids. Enzymatic rate constants however are much higher for the prenyltransferase activity than for the aminopeptidase activity.

Belongs to the tryptophan dimethylallyltransferase family.

472 amino acids

MSIGAEIDSLVPAPPGLNGTAAGYPAKTQKELSNGDFDAHDGLSLAQLTPYDVLTAALPLPAPASSTGFWWRETGPVMSKLLAKANYPLYTHYKYLMLYHTHILPLLGPRPPLENSTHPSPSNAPWRSFLTDDFTPLEPSWNVNGNSEAQSTIRLGIEPIGFEAGAAADPFNQAAVTQFMHSYEATEVGATLTLFEHFRNDMFVGPETYAALRAKIPEGEHTTQSFLAFDLDAGRVTTKAYFFPILMSLKTGQSTTKVVSDSILHLALKSEVWGVQTIAAMSVMEAWIGSYGGAAKTEMISVDCVNEADSRIKIYVRMPHTSLRKVKEAYCLGGRLTDENTKEGLKLLDELWRTVFGIDDEDAELPQNSHRTAGTIFNFELRPGKWFPEPKVYLPVRHYCESDMQIASRLQTFFGRLGWHNMEKDYCKHLEDLFPHHPLSSSTGTHTFLSFSYKKQKGVYMTMYYNLRVYST

52.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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