5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by terf2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways (By similarity).

Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.

571 amino acids

MNGKVLPDTPIAVDCWQLRKCLHVRLFFLSHMHSDHTCGLSSTWSHRPIYCSPLTAKLLRLKLQIKQKWIRPLEIGQDHMLMLDDLGKERLTVNLIDANHCPGAVMFLFQGYFGTRLYTGDFRYTPSMLRVPCLQNHINIDVLYLDNTNCDPTRALPSRQQATQQIKQIIRDHPGYAVVIGLYSLGKESLLVDLAMEFKTWVEVDRERLETLRVLQLPDVFTTDSGAGRIRVVNQSMISASNLMAWNKLQSTIAILPTSRPMVSCHPNVYVVPYSDHSSYQELEDFVSALSPISLVPIVGNCLPYFSSLLSPRKKPKAVVIPESVKQYMMTNSNIRSSTNGMIQRTSRPEVRGVVFDSPETKLSQPNHDDMDSNDTEIDHDTTDRNSDSDCILLDMGTNSYHRDNDQGNKRLKLIRIESEDVVTVTSSLTMDDNESVSTRKGIGSPDPSLIYECDHESPTKSSKEKSPEMGSTNSGEMCSSMDSMHDQTSLTTAAALTLPNPQSVTSAIPITLESEQFEHWLLENFTIPAEELKEGQVLRGLCENYRLNPVDLPKPVGDPLEAAIKRLMSN

64.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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