Catalyzes the retro-aldol cleavage of 4-hydroxy-2-oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds.

Belongs to the 4-hydroxy-2-oxovalerate aldolase family.

351 amino acids

MTRLYLQDVTLRDGMHAIAHRYTADQVRTIAAALDAAGIAAIEVAHGDGLAGSSVNYGHGAASDADWIAAAAEVLTTARLTTLLVPGIGTIADLRAARELGVTSVRIATHCTEADISAQHISWARENGMDVSGFLMMSHMNDPAGLAAQAKLMESYGAHCVYVTDSGGRLLMSDVAERVDAYRQVLEPETQIGIHAHHNLSLGVANSVIAVEHGRILGDGPLGAPAGRTVRVDASLAGQGAGAGNAPLEVFVAVAELHGWEHGCDVFALMDAAEDLVRPLQDRPVRVDRETLSLGYAGVYSSFLRHAERAAERYGVDVRSILIELGRRRMVGGQEDMIVDVALDLAGREKT

37.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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