Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity).

Belongs to the peptidase M67A family. PSMD14 subfamily.

306 amino acids

MNRSLMSLLGREGLGEKITDATPLPDTAETIHISSLALLKMLQHARAGVPLEVMGLMLGELIDEYTIRVIDVFAMPQSGTSVSVEAIDPVFQTKMLDMLKQTGRDEIVIGWYHSHPGFGCWLSSVDVNTQQSFEQLQSRAVAVVVDPLQSVRGKVVIDAFRTIKTSPTAEPRQITSNLGHLQDPSIQALIHGLNRNYYSIAINYRKNELEQKMLLNLHKKKWTEGLIVDKFDTHEQSNEKQINNLLELTKQYQKSIQDEDKIEPEKKEVSAVGKLDPKRHLISDVHTLMANNVVRVLTVMLDTVTF

34.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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