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Protein expression services for PLCZ1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

Description
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
Species
Gallus gallus
Length
637 amino acids
Sequence
MEENRWFLNIIQDGFMNGKIDFDSTVKLLEKLHMPFNLAHVKHVFKKTVDKRKIHTINIEDFRAIYRAIVHRNEFHEIFCAYSENRKNLADTELTAFLKKEQFKTEGAETTALEVILKYEPIDEVRKRRQLSFEGFIRYMSSEDCTIFKKEHRTVYQDMNHPLCDYFISSSHNTYLVSDQLIGPSDLNGYISALLKGCRCLEIDCWDGSNNDPVVYHGHTLTSKITFCSVIHVVDKYAFAASDYPVVLSLENHCSTKQQERIAQYLLNILGDKLLTSPIGDIEVTQLPSPEALKFKILVKNKKCGTIEETMLRKGRDSHGETGEVSEEEITSSDEETDEKTPLYPKSGSSKRKSEGRSSPPPRKKAKVKKMKIAMGLSDLVIYTKSEKFVSFEHSLAHQKCYENNSIGELKAQKFVKHAANQFVSHTSRFITRIYPKGTRAGSSNYNPQEFWNVGCQMVALNFQTSGTPMELQNGKFLDNGGCGYILKPEFLRNRNSTFNPHNVGRYSNPLSLSIRLISGHQLPPSNLSKSNKADPLVQLEIYGVPEDQAKRKSSVIKSNALSPRWDETFSFTVQVPELALIRFCVQDEISLVANDFLGQYTLPLLSLSKGYCTVPLFSKSGGKLEPASLFVYVWYY
Mass
72.5 kDa
Simulated SDS-PAGE
Western blot of PLCZ1 recombinant protein(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)
Safety
Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.
Protein synthesis service
Make PLCZ1 using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)

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