Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield the bicyclic sesquiterpene guaia-6,10(14)-diene via a 1,10-cyclization, which requires the abstraction of the pyrophosphate from FPP to yield the (E,E)-germacradienyl cation. The only accepted substrate is farnesyl diphosphate (FPP).

Belongs to the terpene synthase family.

401 amino acids

MVKFDSGSESEMTNGDDLHINSKHEVKSRMANGNGVHNVPDHDQFQDRAEMEVLILPDLFSSLMSVPARENPHYASVKADADEWISSVINADAKWASRNKRVDFTYLASIWAPDCSAFALRTSADWNSWAFLFDDQFDEGHLSNDLDGAINEIARTREIMEGTAPRYTADSEHPIRYVFQTLCDRVKQSPEGFYAGKPSSERFYRRWMWAHELYWEGLVAQVRTNVEGRSFTRGPEEYLAMRRGSLGAYPALVNNEWAYGIDLPEEVADHPLVFEIMVIMSDQILLVNDILSYEKDLRLGVDHNMVRLLKAKGLSTQQAINEVGVMINNCYRRYYRALSELPCFGEEADRALLGYLEVEKNHALGSLLWSYKTGRYFKSKEDGARVRKTRELLIPKKMAAL

45.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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