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zwl-1

Gene
zwl-1
Protein
Protein zwilch homolog
Organism
Caenorhabditis briggsae
Length
639 amino acids
Function
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores and spindle pole separation. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC80 complex to microtubules. The recruitment of spdl-1 to kinetochores relieves this inhibition. Required for embryonic development.
Similarity
Belongs to the ZWILCH family.
Mass
72.283 kDa
Sequence
MSIKLEDLHSFNEAVLFKGEEDEAPAPVLLLDKYRVRLVPITELPLVSNYSNTSQLGLNSEEVLVIDSPIESAEKQKTSSLLNRRENKKTIKSEKEDESMDMETAEGDKENTVSETGGGPLVTSFLTLDKLEKDGVNDVEIVGLDCEIQFFDANPIPFEDGISLQRFLRLESSKNFSAAVDKLPIWISTIGHHFPSVCWLAAGRTNKNVQVSGATRILGYFNENSQKLVKQLNEACGAAQVNRYRAVYDVIRKIATPTREAPGEVIIDMRWNTKSSLVLLEQPDNAADCTIKIDLGWGDNRFFIDETIFEQLFFVLNLADVLANPEKEVVFRSESDKFDDLVQEMKQLVEACSHEDNVFASNEKSEQVTDKVWNIVRKCSDVKQATMLFKNFLQALTYGKIKSHVQEGNKSHLASLIRASKTCDFRMPILERLSTIEMMMEIGVESLRGRIINKFSDTLQFPSDELTFILKTCENDLSTLEGTLHSSVVSLLPITMAMATIHQIFGFLNVKDLVVLPDLARRVLTKYTTGMVEKAKRGETETDYVFETTLPLLRMNKEAFMHKRPRIWTCENTNTVGANVQTRAMTTLELEPSLEHVCRLVNASRPVRPIDEDNRKPTEEERNADYTVSHTIFSYLPKL

Gene
zwl-1
Protein
Protein zwilch homolog
Organism
Caenorhabditis elegans
Length
630 amino acids
Function
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis (PubMed:18765790). Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores and spindle pole separation (PubMed:18765790). Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex (PubMed:18765790). The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores (PubMed:18765790). To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC80 complex to microtubules (PubMed:24231804). The recruitment of spdl-1 to kinetochores relieves this inhibition (PubMed:24231804). Required for embryonic development (PubMed:18765790, PubMed:19109417).
Similarity
Belongs to the ZWILCH family.
Mass
71.096 kDa
Sequence
MPLTIEQLKQYNEKMAAKGEEDDAPAPVLLLDKYRVRVLPLTSIPFVMNHSSVSQLSLSSEDVLVVDFPSKGTGSGAGKAEKKMIFKKKIEPMEDSFEDKENVNEGGPLMTSFLTLEKLRKGMVGDVEIIGYECETSFFDANPIPLSDGVSLQRYIRLNCSEHFSPSISTLPVWISTTSSKFPSICWLAAGRTNRNVQFAAATRVLGHFNNENSERVVKQLNQACGTSQLNKYRAVYEEIRKIATENRPAPGEVTIDVRWSTKSTLVLLEHPDNAADCTIKIDLGWGDKRFFVDDEIFEQLFFVLNLADVLANPDNEVIFPMAPPANFDDLVQEMDALVEASSREDNVFVSNENFRGGDITDKVWNIVRKCNDVKQVTLLFRNFLQALAYGKIKSHAQERNKSHLASLIRISKSSEFKIPVLERLSTIDMMMEIGVESLRRRVIDIFSSQLLYPSDELEFILQTCENDLPAGNGAMNSAAISLLPITMALATANRIYELLNEKDHVILPDLTRRILQKYTASMIEKSRRGETETEYTFETTLPLLRMYKEGFMSKRPCIWTCENSNTVGANVQARVLTSLELQPSLEHINRLVNDSRPVWTATEEKPAMIKDLNADYTVVHTIFSYLPKM