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zranb1-b

Gene
zranb1-b
Protein
Ubiquitin thioesterase zranb1-B
Organism
Xenopus laevis
Length
701 amino acids
Function
Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. May play a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity).
Similarity
Belongs to the peptidase C64 family.
Mass
79.95 kDa
Sequence
MTEDGIKWACEYCTFENWPSAIKCTMCRAPRPSGAIITEEPFKNRTPDVGSMEREIGSPLICPDSSARPRVKSSYSMETSSKWSCQICTYLNWPRAIRCTQCLSQRRTRSPTESPQSSGSGLRSIPGPIDPCEEYNDRNKLNIKGQHWTCSACTYENCAKAKKCVVCDHPTPNNMDAIELANTDEASSIINEQDRARWRGGCSSSNSQRRSPPTSKRDSDMDFQRIELAGAVGSKEEFELDLKKLKQIKNRMRKTDWLFLNACVGVVEGDLSAVEAYKTSGGDIARQLSADEVRLLNRPSAFDVGYTLVHLSIRFQRQDMLAILLTEVAQHAAKCIPAMVCPELTEQIRREIAASVHQRKGDFACYFLTDLVTFTLPADIEDLPPTVQEKLFDEVLDRDVQKELEEESPIINWSLELGTRLDSRLYALWNRTAGDCLLDSVLQATWGIYDKDSVLRKALHDSLRDCSHWFYSRWKEWESWYSQSFGLHFSLREEQWQEDWAFILSLASQPGASLEQTHIFVLAHILRRPIIVYGVKYYKSFRGETLGYTRFQGVYLPLLWEQSFCWKSPIALGYTRGHFSALVAMENDGFDNRGAGANLNTDDDVTVTFLPLVDSERKLLHVHFLSAQELGNEDQQEKLLREWMDCCVTEGGVLVAMQKSSRRRNHPLVTQMVEKWLDGYRQIRPCTALSDGEEDEDDEDE