Protein
Zinc finger protein ZIC 2-A
Function
Transcriptional repressor that inhibits neurogenesis and induces neural and neural crest differentiation. Regulates anteroposterior patterning in early development by inhibiting expression of the nodal genes through the inhibition of vegt. Required for gastrulation movements and for proper anterior neural and axial development. May also act as a transcriptional activator. May bind to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.
Similarity
Belongs to the GLI C2H2-type zinc-finger protein family.
Sequence
MLLDAGPQFPALGVGTFARHHHHHHHHHAAVAAAAAAAAEMQERELSLAQNTFVEPTHMAAFKLNPGGGSGGGSGGGGGGGGAGPNGGAGASGPHDLSPPGQTSAFTSQAGYPTSALAPHSAYSGAAAFNSPRDFLFRGRGFAEGSAAAGGGQHGLFGPPAGSLHHHPHHHHQLSHAEHPQGHLLFPGIHDQHAAASQNTLGGQMRLGLPGEVFGRTEQYRQVSSPRGDPYTAAQLHNQYSPMNMGMNMAAHHHHHHHHHPGAFFRYMRQPCIKQELICKWIDPEQLNNPKKSCTKTFSTMHELVTHVSVEHVGGPEQSNHICFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPNSETQNPNLSPAAAAVSAVHNVSSGASGALASNFNEWYV