About Products Protein Database Contact

zfyve28

Gene
zfyve28
Protein
Lateral signaling target protein 2 homolog
Organism
Danio rerio
Length
969 amino acids
Function
Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity).
Similarity
Belongs to the lst-2 family.
Mass
106.964 kDa
Sequence
MMNRFRKWLYKPKRSDPQLLAQFYYADEELNQVATELDSLDGRKDPQRCTLLVNQFRSCQDNVLNIINQIMDECIPEERANRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNREIESMAMRPLAKDLTRSLEEVRNITRDQALRDLNHYTERIKEALRHFDGLFAEFELSYVSAMVPVKSPKEYYIQQEVIVLFCETVERALKLEYLTQDMIDDYEPALMFTIPRLAIVCGLVIYSEGPLNLDRKPEDMSELFRPFRTLLRKIRDLLQTLTEEELMTLERSLCISQDGEFPTSSTNDPSASTGPDSQTEELEKEKGVEEVVDLTLFVTQEDSVWKEEEEKQVLPESSSESEEEEPIDADLACSMQYDEEEIEQLNMMVHQVGDEMSTLLSPPSQNQSPAHRPRPYNGSSLEGSSATSSTQASPRRAPGSYHDDDRVFFMDDLESGLSSELCRGQLPLPTVCLRSPEGSSCNGWLTVCQSSDATNLGCQRKLSQSTESVGNSDRMVNGWEGLQDEDSVQTAEEIANRTGGMKLSATVIFNPHSPSLSDLAVVLPQSADAPEGGEGGALVATQCLLNSCVCCAGGCVDNHEDAMEPAGRSMALGFEKHKLTITSSVIQSAVAAGSPGKGNGHLPLTLPPSQGHLTHSVPNCSVQNQAREDEGSQDGIHYPCCEKCSPGVLLAQDRGSGHEGGPSCTLQDTGCQTQHNASVKGRSECFGKQSKDDNRKINSSSQESPLSSVPSSDIDGVSVTTCSLSSSYAPSPVSSLTTSSDMSEDLDHQEIQVALQAAKLAAHNKIRSRFHSSSDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKTDQGDNEKPKKGPCLGSAVLEDCALCQETISSSELAAKAREGQFEDPPEWVPDEACNSCIACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQMKPVRVCTHCYMFHVTPFYSDRTGI

Gene
zfyve28
Protein
Lateral signaling target protein 2 homolog
Organism
Xenopus tropicalis
Length
951 amino acids
Function
Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity).
Similarity
Belongs to the lst-2 family.
Mass
106.143 kDa
Sequence
MMNRFRKWLYKPKRSDPQLLAQFYYADEELNQVAAELDSLDGRKDPQRCTLLVNQFRSCQDNVLNIINQIMEECIAHERANRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNREIESMAMRPLAKDLTRSLEEVRNLIRDQALRDLNIYTEKMKESLRHFDVLFAEFELSYVSAMVPVKSPKEYYVQQEVIVLFCETVERALKLGYLTQDMIDDYEPALMFTIPRLAIVCGLVVYAEGPLNLERKPEDMSELFRPFHTLLRKIRDLLQTLTEDELHTLERNLCISQDVEFPANADPEVPSAISPVLVTALPTEEPPMAKAENTEVELACSMQYDEQELEQLNMMVHRVGDEMSSLLSPPSVYQSPAHRANTSNEASPCRRALDNLTDEEDRVFFMEDLDGSGEVLARSRPSETTISWVNNSCYNAKQPALYQDSVLQNGDLADVVSVKDGQRDISNNNNIDGSKMLAASASLQNSCSCLEAPESQLYLNGWDTNGEDAETAEIIAHRTGGMKISATVIFNPKSLTNSPETSPNLASNRIPSSSDPLTSNEEDESHKLSIAATNCLINSCVCCGSCEDTREDSLEGLRNVPSSGKVINASYSLIKSKELGHLDRSDCTVSAKELLKMDSPTVLLAEKETTRQEQPYPNSSKCLPLNSGSQVEMDSESDEPLTASRDQLRSESNRQETGNKERPSEEVEEPPSDRASADNITSSSSSQDGLRDSALSSISSSDYESVSVTTCSLSSIDSLSSCSSDDIDQEEIQLALQAAKIASRQKIRSRFHSSNDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKQETDDKGKQKKANQGLRSAALEDCALCQETITSSELAAKARDGEFEDPPDWVPDEVCSLCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQMKPVRVCTHCYMFHVTPFYSDRAGM

Gene
Zfyve28
Protein
Lateral signaling target protein 2 homolog
Organism
Mus musculus
Length
905 amino acids
Function
Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity).
Similarity
Belongs to the lst-2 family.
Mass
99.787 kDa
Sequence
MMNRFRKWLYKPKRSDPQLLAQFYYADEELNQVAAELDSLDGRKEPQRCTLLVSQFRSCQDNVLNIINQIMEECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELESMAMRPLAKELTRSLEDVRGTLRDQALRDLNTYTEKMREALRRFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFTIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQALTEEELHTLERSLCVSQDVELPIRADTQAPSALAPTFSASLPPEETLSASANNPEAELACSMQYDDQELEELSRMVHRAGDEMSSLLSPPSACQSPAHRPGSEASPRGEASPARARLKSGSDEEERVFFMDDVEVTESPARPESPGNTFELTQGNAQQRGQDGQSGEVGVEAPALVKEEDWSNNNVEGDKIKLASLMGSTSCSCLDSQLYLDGWEVSAEDAETAEMIAHRTGGMKLSATVIFNPKSPTSQDSAVAAQEAPGHGTSPLEPRAEGTGDNSHKLSTTATNCLLHSCVCCGSCGDSRDDAVERLREKCGPGSVISASNPSVSLAKGGDKEPERIDEAQPSDVTLPAEDASNRQEPKAPASSKCLAHTSGPQVDTASRLQGEGEVKGQPEPEARKQDPEKSPVVSGDSPRGDVAQTEHQHLLGSSSTVGSCSLDNTRLDVATAAMPVTPMATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLKKVTQTLRSAALEDCALCQETVSSSELAAKTRDGDFEDPPEWVPDEACGFCTSCKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSDKTGM

Gene
ZFYVE28
Protein
Lateral signaling target protein 2 homolog
Organism
Homo sapiens
Length
887 amino acids
Function
Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated.
Similarity
Belongs to the lst-2 family.
Mass
96.49 kDa
Sequence
MMNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSLDGRKDPQRCTLLVSQFRSCQDNVLNIINQIMDECIPQDRAPRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRELESMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKMREALRHFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIVLFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCGLVVYADGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTLTEEELHTLERNLCISQDVEFPIRADVQGPAALAPALSAPLPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRAGDEMSSLLSPPIACQSPAHRPGAEGSPGGEASPGRPRLRSGSDEEERVFFMDDVEGTAEALARPESPAGPFGWAGSTWADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTDGASLAGTSSCSCLDSRLHLDGWEVGADDAETAEMIAHRTGGMKLSATVIFNPKSPTSLDSAVATQEAASEPVAEGMDGGPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCSPGGVIGASYAAGLAKASDRAPERQEEAPPPSEDASNGREPKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQEPEARELHAGSPSAHEAPQALSGSSSSTAGSCSSDKMGPEAAPAATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLRSAALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEACGFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQVKPVRVCTHCYMFHVTPFYSDKAGL