Protein
Lateral signaling target protein 2 homolog
Function
Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity).
Similarity
Belongs to the lst-2 family.
Sequence
MMNRFRKWLYKPKRSDPQLLAQFYYADEELNQVATELDSLDGRKDPQRCTLLVNQFRSCQDNVLNIINQIMDECIPEERANRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNREIESMAMRPLAKDLTRSLEEVRNITRDQALRDLNHYTERIKEALRHFDGLFAEFELSYVSAMVPVKSPKEYYIQQEVIVLFCETVERALKLEYLTQDMIDDYEPALMFTIPRLAIVCGLVIYSEGPLNLDRKPEDMSELFRPFRTLLRKIRDLLQTLTEEELMTLERSLCISQDGEFPTSSTNDPSASTGPDSQTEELEKEKGVEEVVDLTLFVTQEDSVWKEEEEKQVLPESSSESEEEEPIDADLACSMQYDEEEIEQLNMMVHQVGDEMSTLLSPPSQNQSPAHRPRPYNGSSLEGSSATSSTQASPRRAPGSYHDDDRVFFMDDLESGLSSELCRGQLPLPTVCLRSPEGSSCNGWLTVCQSSDATNLGCQRKLSQSTESVGNSDRMVNGWEGLQDEDSVQTAEEIANRTGGMKLSATVIFNPHSPSLSDLAVVLPQSADAPEGGEGGALVATQCLLNSCVCCAGGCVDNHEDAMEPAGRSMALGFEKHKLTITSSVIQSAVAAGSPGKGNGHLPLTLPPSQGHLTHSVPNCSVQNQAREDEGSQDGIHYPCCEKCSPGVLLAQDRGSGHEGGPSCTLQDTGCQTQHNASVKGRSECFGKQSKDDNRKINSSSQESPLSSVPSSDIDGVSVTTCSLSSSYAPSPVSSLTTSSDMSEDLDHQEIQVALQAAKLAAHNKIRSRFHSSSDLIHRLFVCISGVADQLQTNYASDLRSILKTLFEVMATKTDQGDNEKPKKGPCLGSAVLEDCALCQETISSSELAAKAREGQFEDPPEWVPDEACNSCIACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPRYGQMKPVRVCTHCYMFHVTPFYSDRTGI