zfpm1

Zinc finger protein ZFPM1

1061 amino acids

Transcription regulator that plays an central role in red blood cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1 and GATA2. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Acts as a repressor of red blood cells, probably by modulating activity of GATA1.

Belongs to the FOG (Friend of GATA) family.

114.181 kDa

single

WNGPDELELEISSTDGVGHIRARNQLHKGFSWGPYKGNFTGSSSSPGPADLNISPSWDVDGDCWLKYVTLVSCEAEANAVLYRKGDLIWCKTSQIVEQDEVIQAFLKAEPQAIPNYTIKEEPGETSQCTSTLPEFQLLPQQAGMAAILATAVVNKDVFPCKDCGIWYRSERNLQAHLMYYCASRQSSTSPSMEEKAKDSYPNERICPFPQCKKSCPSTSSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLNGVCHGCGFISTTRDILYSHLVTNHMICQPGSKVDVYPVVKAVPAVKSSNPVVSQIASSSLLKCGLCGFLAEDFQVFNHALLHTTNPVPSATHSVKSPPENINEKQNPESQENGNAKSPISSSSSASSRSEETPLKLYIKQEPEGQLSISEAGSTTCEAKDGVALVQSPAIKVKTEMSSPTPGSSPVPNETGAATGGGTVIIPHYVFGHEATAAIVPQASEILAKMSELVHSRLKQGQAVTPAGFSGSAVPKGATCFECEITFNNINNYYVHKRLYCSGRHVSDENSSSARKVKALPARTALASGFSSTEQEASPPQEDAGEESSAPVVAVKLEENSGMDCEGAGSGHVSEGSQSPSSLDDPEEDPNRTVCGACNIRFSRHETYVVHKRYYCASRHDPPLRRREVNKPGPPYTTQPTPRTRKRRKLYEIHGVAPTESTPPSPHTLGRVEAMALMPGLIPAPVMPSPSSSPDAVDGPIDLSKKPRLVAEAPVPSAAATVAPLADYHECTACRISFNSLESYLAHKKFSCPTAPLQQKTIQQLQKVKSPSSATGKLVDDTVKVKVESKAALSPGSVSDTIQPLALPFSTISDPKQLQQYSSVTEASLSATTTCPYCPHNVIIRGDLLEHFRSVHGLILAKPTAGHRLQTTIMEVLVPARGQTSSASENSLPSPPVSSASPLQLPGLRRENSNYKDTTSSSSSVNGSPILTSTPRPLLPTSPAPPSNSLPLAESRREDGLPRVPSQVLLPGDKAMQPPKPSLISPVPNGNHRYCRLCNIKFSSLSTFIAHKKYYCSSHAAEHVK

ZFPM1

Zinc finger protein ZFPM1

1006 amino acids

Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).

Belongs to the FOG (Friend of GATA) family.

104.888 kDa

MSRRKQSNPRQIKRSLGDMEAREEVQLVGASHMEQKATAPEAPSPPSADVNSPPPLPPPTSPGGPKELEGQEPEPRPTEEEPGSPWSGPDELEPVVQDGQRRIRARLSLATGLSWGPFHGSVQTRASSPRQAEPSPALTLLLVDEACWLRTLPQALTEAEANTEIHRKDDALWCRVTKPVPAGGLLSVLLTAEPHSTPGHPVKKEPAEPTCPAPAHDLQLLPQQAGMASILATAVINKDVFPCKDCGIWYRSERNLQAHLLYYCASRQGTGSPAAAATDEKPKETYPNERVCPFPQCRKSCPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLSGVCHSCGFISTTRDILYSHLVTNHMVCQPGSKGEIYSPGAGHPATKLPPDSLGSFQQQHTALQGPLASADLGLAPTPSPGLDRKALAEATNGEARAEPLAQNGGSSEPPAAPRSIKVEAVEEPEAAPILGPGEPGPQAPSRTPSPRSPAPARVKAELSSPTPGSSPVPGELGLAGALFLPQYVFGPDAAPPASEILAKMSELVHSRLQQGAGAGAGGAQTGLFPGAPKGATCFECEITFSNVNNYYVHKRLYCSGRRAPEDAPAARRPKAPPGPARAPPGQPAEPDAPRSSPGPGAREEGAGGAATPEDGAGGRGSEGSQSPGSSVDDAEDDPSRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPAAPPGPPGPAAPPAPSPAAPVRTRRRRKLYELHAAGAPPPPPPGHAPAPESPRPGSGSGSGPGLAPARSPGPAADGPIDLSKKPRRPLPGAPAPALADYHECTACRVSFHSLEAYLAHKKYSCPAAPPPGALGLPAAACPYCPPNGPVRGDLLEHFRLAHGLLLGAPLAGPGVEARTPADRGPSPAPAPAASPQPGSRGPRDGLGPEPQEPPPGPPPSPAAAPEAVPPPPAPPSYSDKGVQTPSKGTPAPLPNGNHRYCRLCNIKFSSLSTFIAHKKYYCSSHAAEHVK

Zfpm1

Zinc finger protein ZFPM1

995 amino acids

Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.

Belongs to the FOG (Friend of GATA) family.

105.984 kDa

MSRRKQSNPRQIKRSLRDMEAGEEAKAMDSSPKEQEAPDPEAPAIEEPPSPPREDVSPPAVPAPPESPEDPEDMEGQELEMRPQDEEKEEKEEEAAMASPWSGPEELELALQDGQRCVRARLSLTEGLSWGPFYGSIQTRALSPEREEPGPAVTLMVDESCWLRMLPQVLTEEAANSEIYRKDDALWCRVTKVVPSGGLLYVRLVTEPHGAPRHPVQEPVEPGGLAPVHTDIQLLPQQAGMASILATAVINKDVFPCKDCGIWYRSERNLQAHLLYYCASRQRAGSPVSATEEKPKETYPNERVCPFPQCRKSCPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLSGVCHNCGFISTTRDILYSHLVTNHMVCQPGSKGEIYSPGAGHPAAKLPPDSLAGFQQHSLMHSPLVPADKAPTPSSGLDSKAEVTNGETRVPPQNGGSSESPAAPRTIKVEAAEEPEATRASGPGEPGPQAPSRTPSPHSPNPVRVKTELSSPTPGSSPGPGELTMAGTLFLPQYVFSPDAGTTTVPTAPQASEILAKMSELVHNRLQQGAGSSGAAGTPTGLFSGTKGATCFECEITFNNINNFYVHKRLYCSGRRAPEDPPTVRRPKAATGPARAPAGAAAEPDPSRSSPGPGPREEEASGTTTPEAEAAGRGSEGSQSPGSSVDDAEDDPSRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPPAPTTAPGPAAPALTAPPVRTRRRRKLYELPAAGAPPPAAGPAPVPVVPSPTAELPSSPRPGSASAGPAPALSPSPVPDGPIDLSKRPRRQSPDAPTALPALADYHECTACRVSFHSLEAYLAHKKYSCPAAPLRTTALCPYCPPNGRVRGDLVEHLRQAHGLQVAKPAASPGAEPRTPAERAPRDSPDGRAPRSPSPAPENTPSDPADQGARTPSKGPPAPAPAPGGGGGHRYCRLCNIRFSSLSTFIAHKKYYCSSHAAEHVK

zfpm1

Zinc finger protein ZFPM1

224 amino acids

Transcription regulator that modulates expression mediated by transcription factors of the GATA family. Cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context (By similarity).

Belongs to the FOG (Friend of GATA) family.

23.956 kDa

single

MSEMVHSRLKQGQGPAAAQQSFYPPGSPASVHKGATCFECDITFNNINNFYVHKRLYCSSRHQQGETGGLVKEGAVTAAAPPVSHAASPQARPVSRAASASPSCPDPAPGGTASEPKVVEVKIEDPGLKDATCSSSSEGEGPGGGQASEGSQSPSGSAEDQDDDPTRTFCQACNIRFSRHDNYIVHKRFYCASRHDPTNQRPHSGKAAFLPQPIRTRKRKKMYE