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zcchc4

Gene
ZCCHC4
Protein
rRNA N6-adenosine-methyltransferase ZCCHC4
Organism
Bos taurus
Length
516 amino acids
Function
rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation.
Similarity
Belongs to the ZCCHC4 family.
Mass
59.485 kDa
Sequence
MATSRDRLGTLEAEGSSGRQGYSGVEVVLSSDPATPAPLCPHELGPTLLFVKVNQGKEETRRFYACSACRDRKDCNFFQWEDEKLSGARLAAREAHNRSCQPPLSRSQCVERYLKFIELPLSQRKFCQSCQQLLLPDDEEKHHEHQVVGDVSITQLKRPSKLLYPLENKKTNAQYLFADRSCLFLVDLLSNLGFRRVLCVGTPRLHELIRLKESGGTKSNIRSLLLDIDFRYSQFYMEDSFCHYNMFNHHFFDGKAALEVCKTFLQEDKGEGVIMVTDPPFGGLVEPLAVTFKKLIAMWKEGHSQDNSQKELPIFWIFPYFFESRICQFFPSFCMLDYQVVDYDNHALYKHGKTGRKQSPVRIFTNIPPNKIILPIEEGYRFCPLCQRYVSLENQHCEHCNSCTSKDGRKWNHCFLCKKCVKPSWIHCSICNHCALPDHSCKGPKDGCFICGELDHKRSACPNISTSKKVNKAVRKQKQRKSNKMKMETTKGQSMNHTSATRKKKRRERTHQYLCS
Protein
rRNA N6-adenosine-methyltransferase ZCCHC4: ZCCHC4

Gene
ZCCHC4
Protein
rRNA N6-adenosine-methyltransferase ZCCHC4
Organism
Homo sapiens
Length
513 amino acids
Function
rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA (PubMed:30531910). N6-methylation of adenine(4220) in 28S rRNA is required for translation (PubMed:30531910).
Similarity
Belongs to the ZCCHC4 family.
Mass
59.01 kDa
Sequence
MAASRNGFEAVEAEGSAGCRGSSGMEVVLPLDPAVPAPLCPHGPTLLFVKVTQGKEETRRFYACSACRDRKDCNFFQWEDEKLSGARLAAREAHNRRCQPPLSRTQCVERYLKFIELPLTQRKFCQTCQQLLLPDDWGQHSEHQVLGNVSITQLRRPSQLLYPLENKKTNAQYLFADRSCQFLVDLLSALGFRRVLCVGTPRLHELIKLTASGDKKSNIKSLLLDIDFRYSQFYMEDSFCHYNMFNHHFFDGKTALEVCRAFLQEDKGEGIIMVTDPPFGGLVEPLAITFKKLIAMWKEGQSQDDSHKELPIFWIFPYFFESRICQFFPSFQMLDYQVDYDNHALYKHGKTGRKQSPVRIFTNIPPNKIILPTEEGYRFCSPCQRYVSLENQHCELCNSCTSKDGRKWNHCFLCKKCVKPSWIHCSICNHCAVPDHSCEGPKHGCFICGELDHKRSTCPNIATSKRANKAVRKQKQRKSNKMKMETTKGQSMNHTSATRRKKRRERAHQYLGS
Protein
rRNA N6-adenosine-methyltransferase ZCCHC4: ZCCHC4

Gene
Zcchc4
Protein
rRNA N6-adenosine-methyltransferase ZCCHC4
Organism
Mus musculus
Length
512 amino acids
Function
rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation.
Similarity
Belongs to the ZCCHC4 family.
Mass
58.567 kDa
Sequence
MAAPMDCLESLEGDGDAGRRASGVEVALPSNPTAPAPLCPHGPTLLFVKVNQGKEETRKFYACSACRDRKDCNFFQWEDEKLSEARLAAREIHNQKCQPPLSRAQCIERYLSFIQLPLAQRKFCQSCQQLLLPADWREHGTHQLSADISVAQLGRPSQLLYPLENKKTHAQYLFADRSCQFLAGLLATLGFSRVLCVGAPRLHEQIRLTASGERSGMRSLLLDIDFRYSQFYLEGSFCRYNMFNHHFFDGKAALEVCKEFLQEEEGKGVIMVTDPPFGGLVEPLAITFKKLIAMWKEGQSQDDSHKELPIFWIFPYFFESRICQFFPSFCMLDYQVDYDNHALYKHGKTGRKQSPVRIFTNVPPNKIILPSEEGYRFCSLCQRYVSRENQHCVHCNSCTSKDGRKWSHCFLCKKCVKPSWIHCNTCNRCALPDHSCLGPKDGCFICGALDHKRSNCPNIGTSWRANKLVEFFGFLEKRLLMSSFLGAIYRSTKLSEDSEFFRVLNRSSHHYV
Protein
rRNA N6-adenosine-methyltransferase ZCCHC4: Zcchc4

Gene
zcchc4
Protein
rRNA N6-adenosine-methyltransferase ZCCHC4
Organism
Xenopus laevis
Length
489 amino acids
Function
rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation.
Similarity
Belongs to the ZCCHC4 family.
Mass
56.035 kDa
Sequence
MEAAEGSENYDGIQVLLSREVIDTAPQCPHGPTLLFVKVSQGKEQGRRFYACSACRDRKDCHFFQWEDEKVSQARLAAREEYNKSHQPPMTHAEYARSFQEFTALPLAKRKFCCDCQQLLLQTNWETHSRHRVLGDISLSQLKRPSQLLHPLENKKANAQYLFADRSCTFLLDTIIALGFRRVLCVGTPRLHELIKLRACKGTTPPIKSLLLDIDFRYSQFYSEEEFSHYNMFNHHFFGGEAAKLVCQKFLQEEDGNGALLVTDPPFGGLVEPLAFSFKRLREMWKDSNPENANNLPIFWMFPYFFESRILQCFPDFAMLDYQVDYDNHALYKHGKTGRKQSPVRIFTDLPLDKIVLPASEGYRFCSVCERFVCSENKHCDICNRCTSKDGRSWKHCSQCKKCVKPSWSHCSACNHCALPGHPCGTAGDGCFLCGGKGHKRRGCPHLSVSADGERMKRNLKQRSIKGNMKKQPTATTSKKKKRKRNNPC
Protein
rRNA N6-adenosine-methyltransferase ZCCHC4: zcchc4

Gene
Zcchc4
Protein
rRNA N6-adenosine-methyltransferase ZCCHC4
Organism
Rattus norvegicus
Length
489 amino acids
Function
rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation.
Similarity
Belongs to the ZCCHC4 family.
Mass
56.027 kDa
Sequence
MAAPMDCLESLEGEGSVGRRASGVEVALPSNPGAPAPQCPHGPTLLFVKVSQGKEEPRKFYACSACRDRKDCNFFQWEDEKLSEARLAAREIHNQRCQPPLSRAQCIERYLSFIQLPLTQRKFCRSCQQLLLPADWREHGEHQLSADISTTQIARPSQLLYPLENKKTHAQYLFADRSCQFLAGLLATLGFRRVLCVGAPRLHEQIRLTAPGEKPDMRSLLLDIDFRYSQFYLEESFCRYNMFNHHFFDGKAALEVCKAFLQEEEGKGVIMVTDPPFGGLVEPLAVTFKKLIAMWKEGQSQDDSHKELPIFWIFPYFFESRICQFFPSFCMLDYQVDYDNHALYKHGKTGRKQSPVRIFTNIPPNKIILPSEEGYRFCSVCQRYVSRENQHCVHCNSCTSKDGRKWSHCFFCKKCVKPSWIHCNTCNRCALPDHSCLGPKDGCFICGSLDHKRSNCPSIGASQRANNAVRKQKQRKSNKIRREALKDNP
Protein
rRNA N6-adenosine-methyltransferase ZCCHC4: Zcchc4

Gene
zcchc4
Protein
rRNA N6-adenosine-methyltransferase ZCCHC4
Organism
Xenopus tropicalis
Length
487 amino acids
Function
rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation.
Similarity
Belongs to the ZCCHC4 family.
Mass
55.773 kDa
Sequence
MEGAEGSDSCDGIQVLLSREVIDAAPQCPHGPTLLFVKVSQGKEQGRRFYACSACRDRKDCHFFQWEDDKVSQARLAAREEYNKSHQPPMTHAQYVGRFQEFTELPLAKRKFCSDCQQLLLPTNWESHSGHRVLGDISLSQLKRPSQLLHPLENKKANAQYLFAERSCTFLMDTIIALGFRRVLCVGTPRLHELIKLRACEGATPPIKSLLLDIDFRYSQFYWEEEFCHYNMFNHHFFGGEAAKMVCQKFLQEEDGKGALLVTDPPFGGLVEPLAFSFKRLREMWKTTNPENESNLPILWMFPYFFESRILQCFPDFTMLDYQVDYDNHALYKHGKTGRKQSPVRIFTDLPPDKIVLPAIEGYRFCSVCERFVCSGNKHCNICNCCTSKDGRPWKHCTQCNKCVKPSWTHCSACNHCALPDHPCGTAGRGCFLCGGKDHKRRGCPHQSVSAHGKRMENLKQKNIKGSMKKQPIAATSKKRKRKRNNP
Protein
rRNA N6-adenosine-methyltransferase ZCCHC4: zcchc4