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ywlE

Gene
ywlE
Protein
Protein-arginine-phosphatase
Organism
Bacillus subtilis (strain 168)
Length
150 amino acids
Function
Catalyzes the specific dephosphorylation of phosphoarginine residues in a large number of proteins. Counteracts the protein arginine kinase McsB in vivo. Can dephosphorylate CtsR-P; thus, can restore the DNA-binding ability of the CtsR repressor by reversing the McsB-mediated phosphorylation. Is the only active pArg phosphatase present in B.subtilis. Exhibits almost no activity against pSer, pThr, or pTyr peptides. Appears to play a role in B.subtilis stress resistance. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.
Similarity
Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
Mass
16.785 kDa
Sequence
MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPNGKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKVFTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR

Gene
ywle
Protein
Protein-arginine-phosphatase
Organism
Geobacillus stearothermophilus
Length
148 amino acids
Function
Catalyzes the specific dephosphorylation of phosphoarginine residues in proteins. Probably counteracts the protein arginine kinase McsB in vivo. Exhibits almost no activity against pTyr peptides. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.
Similarity
Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
Mass
16.3 kDa
Sequence
MPYRILFVCTGNTCRSPMAAALLENKQLPGVEVKSAGVFAAEGSEASVHAKMVLKEKGIEAAHRSSQLKKEHIDWATHVLAMTSGHKDMIVERFPEAKDKTFTLKQFVSGTDGDIADPFGGPIEVYRAARDELETLIDRLAEKLQTEQ