Protein
Effector protein YopJ
Organism
Yersinia pseudotuberculosis serotype I (strain IP32953)
Function
Blocks the innate immune response by blocking cytokine production and inducing apoptosis in the infected cells. Inhibits the MAPK and NF-kappa-B signaling pathways by acetylating MAP2K1, MAP2K6 and probably also MAP2K3, MAP2K4 and I-kappa-B kinase on residues critical for their activation by phosphorylation, thus preventing it.
Similarity
Belongs to the peptidase C55 family.
Sequence
MIGPISQINISGGLSEKETSSLISNEELKNIITQLETDISDGSWFHKNYSRMDVEVMPALVIQANNKYPEMNLNLVTSPLDLSIEIKNVIENGVRSSRFIINMGEGGIHFSVIDYKHINGKTSLILFEPANFNSMGPAMLAIRTKTAIERYQLPDCHFSMVEMDIQRSSSECGIFSFALAKKLYIERDSLLKIHEDNIKGILSDGENPLPHDKLDPYLPVTFYKHTQGKKRLNEYLNTNPQGVGTVVNKKNETIVNRFDNNKSIVDGKELSVSVHKKRIAEYKTLLKV