Protein
Probable ribonuclease YokI
Organism
Bacillus subtilis (strain 168)
Function
Toxic component of a type II toxin-antitoxin (TA) system. The C-terminus (residues 449-571) inhibits growth upon expression in E.coli which is neutralized by cognate antitoxin YokJ, but not by antitoxins specific to other toxins with the LXG domain.
Sequence
MKVFEADSLLSEADKRTKEYKELRSQMVKLKKAFKAVADLDDSKFSGKGADNIKAFYHDHVGVTDQWIDLIDMKIVFLSSISAKLEDAKMSDAYIEESFLEHELVNAYTKSKSIMSEQKKAMKDILNDINDILPLEIFSTEDFKDKLSSADDKREKTIDKINKLDEDLKTEYAETEQNEQFIQQDFKKLQESTGKGKNATPIHYSAKAYRESDIHKKKGDIEQHSEAYLTVKKEEAKEREIKELKKKLNDGVSDPDEYLEIAKKVGYENLEPAQVQLAVQIEQAKQLEGAGEITWDIVKGVGVGLYDVGKDTVTGLWDFITDPGETLSALGNAVIHPVKTYDAISAAIEESYQKDMVNGDAYSRSRWVTYAIGSVAAAVIGTKGAGAINKADAAGKVINKASQAGKKIKDVKIPDLLPYNPKYDLAMAGDVPYNVVDGENLKNQLMSFAKGSDKEVKPFDVVDYRPSNSPLENHHGVMDVWAKHNVPNYVSRGSNTPTVALTKEQHNATKKVYREWLFEKTGKKVGGKVNWKEVSPREIQELTEKMFDAANVPKEARQQYYNAFNQYNFRK