yju2

Splicing factor YJU2

345 amino acids

Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex (PubMed:22952453).

Belongs to the CWC16 family. YJU2 subfamily.

38.858 kDa

MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNELYLGLPIFRFYIKCTRCLAEITFKTDPENTDYAMEHGATRNFQAEKLIEEEEKKIQQEREDEELNNPMKVLENRTRDSKLEMEVLENLQELKELNQRQAQVDFEGMLGQYKELEQRQKQREQEEDEQETKEMLERALVKRLRDSDSEEEAENAKERSKKHIADKPTDILTTDTSTSSQGLSSAVAKKQSWDRSVGGLSVKGALGSLVVRKKPADSASKPSHAAPPPAAAAAGTQTGAVKPESSITSSSASSNIQPVSCQNGSSLGLLGAYSDSDDSSSD

yju2

Splicing factor YJU2

324 amino acids

Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.

Belongs to the CWC16 family. YJU2 subfamily.

37.472 kDa

MGERKVISKYYPPDFDPSKVAKIKVKRPTFTKVTTMLPMSIRCNTCGEYIGRGTKFNAKKETVQNEDYLGIKIYRFFLRCKKCAAELTIKTDPKNSEYVCESGATRNYEPWKETDEEKSNRMTKEQEEEQDAMIALENRTLESKREMEMLDALEEIKSLNSRNSEIDTEQLLEYNLQKQELEEKLQDEEDDLLVKSIFNNKNKLELNQINDNNSINNNIDSNKIKRIENDDDDGDKFNSLFSNNNKNNKNIINNNNNNNNNINTTSISNTIETTPTTNQKTSILGNKVKVVINKQEEPIPKNNNNSEPNSFSSFMSAYSDDEED

YJU2

Splicing factor YJU2

323 amino acids

Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA (PubMed:29301961). Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (By similarity). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex (PubMed:22952453).

Belongs to the CWC16 family. YJU2 subfamily.

37.086 kDa

MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNEVYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTMEHGATRNFQAEKLLEEEEKRVQKEREDEELNNPMKVLENRTKDSKLEMEVLENLQELKDLNQRQAHVDFEAMLRQHRLSEEERRRQQQEEDEQETAALLEEARKRRLLEDSDSEDEAAPSPLQPALRPNPTAILDEAPKPKRKVEVWEQSVGSLGSRPPLSRLVVVKKAKADPDCSNGQPQAAPTPGAPQNRKEANPTPLTPGASSLSQLGAYLDSDDSNGSN

Yju2

Splicing factor YJU2

314 amino acids

Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.

Belongs to the CWC16 family. YJU2 subfamily.

35.988 kDa

MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNEAYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTMEHGATRNFQAEKLLEEEEKRVQKEREDEELNNPMKVLENRTKDSKLEMEVLENLQELKDLNQRQAHVDFEAMLRQHRMSQEQWQQQQEEEDERETAALLEEARHRRLLEDSESEDEAPPSRPRAAARPNPTAILNEVPQTKRKAEALCSKAQLAGLVVPKKVKTEANGASEQVGVPTAAGAPKSRKADNPTPQTPGTSSLSQLGAYGDSEDSDS

YJU2

Splicing factor YJU2

278 amino acids

Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA (PubMed:19935684, PubMed:27445308, PubMed:27459055, PubMed:29146871). Plays a role (via N-terminus) in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates (PubMed:23438600, PubMed:27459055). Further stabilizes spliceosome conformation for 3'-splice site docking (via C-terminus) promoting exon ligation (PubMed:29146871).

Belongs to the CWC16 family. YJU2 subfamily.

32.312 kDa

MSERKAINKYYPPDYNPLEAEKLSRKMAKKLKTMNKSHASIRLMTPFSMRCLECNEYIPKSRKFNGKKELLKEKYLDSIKIYRLTISCPRCANSIAFRTDPGNSDYVMEVGGVRNYVPQKPNDDLNAKTAVESIDETLQRLVREKEMEQNEKMGIKEQADDKMDLLEKRLAKIQQEQEDDEELENLRKKNLEMSQRAEMINRSKHAQQEKAVTTDDLDNLVDQVFDNHRQRTNKPGNNNDEKRTPLFNPTSTKGKIQKKSSVRTNPLGIVIKRGKSLK