Protein
NADH-specific methylglyoxal reductase
Organism
Escherichia coli (strain K12)
Function
Catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro (PubMed:16813561). It is not known if this activity has physiological significance (PubMed:16813561). Cannot use NADPH as a cosubstrate (PubMed:16813561). Seems to play some role in intestinal colonization (PubMed:20562286).
Similarity
Belongs to the aldo/keto reductase family. Aldo/keto reductase 11 subfamily.
Sequence
MKKIPLGTTDITLSRMGLGTWAIGGGPAWNGDLDRQICIDTILEAHRCGINLIDTAPGYNFGNSEVIVGQALKKLPREQVVVETKCGIVWERKGSLFNKVGDRQLYKNLSPESIREEVAASLQRLGIDYIDIYMTHWQSVPPFFTPIAETVAVLNELKSEGKIRAIGAANVDADHIREYLQYGELDIIQAKYSILDRAMENELLPLCRDNGIVVQVYSPLEQGLLTGTITRDYVPGGARANKVWFQRENMLKVIDMLEQWQPLCARYQCTIPTLALAWILKQSDLISILSGATAPEQVRENVAALNINLSDADATLMREMAEALER