xrn-2

5'-3' exoribonuclease 2 homolog

976 amino acids

Possesses 5'->3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Degradation role is enhanced when in complex with paxt-1. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle.

Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.

111.453 kDa

MGVPAFFRWLTKKYPATVVNANEDRQRGVDGRRVPVDCTQPNPNFQEFDNLYLDMNGIIHPCTHPEDRPAPKNEDEMFALIFEYIDRIFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEMAEKAASIEEQRRRLIAEGIAVPQKKKDEEEAHFDSNCITPGTPFMARLADALRYYIHDRVTNDPAWANIEIILSDANVPGEGEHKIMDYIRKQRGNPAHDPNTVHCLCGADADLIMLGIATHEANFNIIREEFVPNQPRACELCGQYGHELKECRGAENDTDLGDEYCKPEQREKNFIFLRIPVLREYLEKEMAMPNLPFQFNLERALDDWVFLCFFVGNDFLPHLPSLEIREGAIDRLIKLYKEMVYEMKGYLTKDGIPELDRVEMIMRGLGKVEDEIFKRRQQDEERFKENQKNKKARMQQYGRGRGGRGRGRGQPAYVPSHGILAPMSAPMHHSGESTRQMASDARQAAMQFNATNDANAQAAANLKALLNVKGEQSPAEVAAQESRKRKAEQPIIITDEDEEPKDDIRLYESGWKERYYRAKFDVGSDDVDFRHRVAWAYVEGLCWVLRYYYQGCSSWDWYFPYHYAPFASDFETVGEFKPDFTRPTKPFNPLEQLMSVFPAASKQHLPVEWQKLMTEDESPIIDLYPADFRIDLNGKKYAWQGVALLPFVDEQRLLETLKSVYPTLTDEEKYRNTRGPNRIFIGRNHKSFAFFQQVAESKSNDLVDLDPSLLNGVSGKISYDSTATAPGLPFPSPVSHEECQDLPTNCGICVLYEDPEYPANYVFPAVRLDGAKEAEKTLRPEDWNERRDGRFNPTIGFNRNAPRGGLDLSGQRHINHHVRGAMYDRQGGNDNYRGGYRGGYQGGYDDRRGGRGGGGYRGGYNDSRPDFGRNYAGREGGGPQHYHEHQPGGGHGRPHDQQPYQDNRRGGGYHRGGRGNGPTGYQRPPYRGGRGRGGGGYQGNSSWR

xrn-2

5'-3' exoribonuclease 2 homolog

975 amino acids

Possesses 5'->3' exoribonuclease activity (PubMed:19734881, PubMed:21397849). Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA (PubMed:19734881, PubMed:21397849, PubMed:26779609). Degradation role is enhanced when in complex with paxt-1 (PubMed:24462208, PubMed:26779609). Partially redundant to xrn-1 in miRNA guide strand degradation (PubMed:19734881, PubMed:21397849). Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA (PubMed:19734881, PubMed:21397849). Positively regulates molting of the pharyngeal cuticle (PubMed:16122351, PubMed:19734881).

Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.

110.128 kDa

MGVPAFFRWLTKKYPATVVNANEDRQRDQDGNRVPVDCTQPNPNFQEFDNLYLDMNGIIHPCTHPEDRPAPKNEDEMFALIFEYIDRIYSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEMAEKEASIEEQRNRLMAEGIAVPPKKKEEAHFDSNCITPGTPFMARLADALRYYIHDRVTNDASWANIEIILSDANVPGEGEHKIMDYVRKQRGNPAHDPNTVHCLCGADADLIMLGIATHEANFNIIREEFVPNQPRACDLCGQYGHELKECRGAENETDLGDDYCKPEQREKNFIFLRIPVLREYLEKELSMPNLPFKFDVERALDDWVFLCFFVGNDFLPHLPSLEIREGAIDRLIKLYKEMVYQMKGYLTKDGIPELDRVEMIMKGLGRVEDEIFKRRQQDEERFQENQRNKKARMQMYGGGGRGGRGRGRGRGQQPAFVPTHGILAPMAAPMHHSGESTRQMASEARQTAMKFTNDANETAAANLKALLNVKGEESPADIASRKRKAEQPLIKPEEEEDEGPKDDIRLYESGWKDRYYRAKFDVGSDDIEFRHRVAWAYVEGLCWVLRYYYQGCASWDWYFPYHYAPFASDFETVGEFQPDFTRPTKPFNPLEQLMSVFPAASKQHLPVEWQKLMIQDDSPIIDLYPADFRIDLNGKKYAWQGVALLPFVDETRLLATLQSVYPTLTAEEKQRNTRGPNRIFIGRNHKSFEFFQQVAESKSDDLVPLDPTLLNGVSGKIAYDSTATAPGLPFVSPVNHDECQDLPTNCGICVLYEDPEYPQDYIFPALRLDGAKEPEKTLKPDDWNDRRDGRYQPQVGFNRNAPRGSLDQSGHRQVHHYVRGGGGGGGGYRGNSYDDRRGGGGGGGGYNDRQDFGRNYGGRDGGGPQRYHDQQQQRQGGYQGGGYGGGYGGGGGGGGGGGGGSYHQPYNQDQRRGGRGGGGGPPGYQRPPYRGGGGGGYHGNSSWR