Protein
Dehydrogenase xptC
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Function
Dehydrogenase involved in the conversion of monodictyphenone to the prenyl xanthones such as emericellin, shamixanthone and epishamixanthone (PubMed:21351751, PubMed:22730213). Monodictyphenone is first converted to variecoxanthone A via a paeciloxanthone intermediate by the consecutive actions of the FAD-dependent monooxygenase mdpD and the xanthone prenyltransferase xptB (PubMed:21351751). XptB catalyzes regular O-prenylation at the hydroxy group of C-7 of the xanthone ring (PubMed:23150454). Variecoxanthone A is further prenylated to emericellin by xptA before being reduced to shamixanthone and epishamixanthone by the dehydrogenase xptC (PubMed:21351751).
Similarity
Belongs to the GMC oxidoreductase family.
Sequence
MAKLSVILLFRSLLLCGALTVSRHATLVTEREVQSSKYDFIVVGGGVSGLTVADRLTEIPDVSVLVIEAGPVDRGEDFVYVPGSYERDPYIWPGLTNEPSAELNNRVFDSVVARVAGGGSIVNAMIFLRGTALDFDGWESLGNHGWGWEGMLPYFIKSENFTRPTPELAHEGNITWDDSVRGHDGPVRYSYPNYIYPGLGRLYEAALHIGIQPRLDPNGGQNTGVFNQPFAIDAATWTRSSARRNHYDPAVSRPNYHFLSDTTVARVIFDGTRAVGVEYLPSRGGGISTAFAAKEVLVAAGALHTPQVLQLSGVGPRDLLEALNIPIISDLPGVGSNLQDQTTFPFVYTWDSAVTPNVTTFLTNTTWATEQRVLYDQHLPSVWTLTRPLAPKFAFLSYEDATANTAYASILDDAQARDPADSLPGDIHPTVLAGYAVQRQIMFNEFRDAGLAVGGMSWDTDANVQVFNVKPFSRGYVYINQTDPLANPVIDFRTASDPTDFQLHIALLHKQRELFNAPSLAALGPTEVVPGPAVQTDEDIIKLMREILQPSNGHQCCSAPMMPRELGGVLSPEMKVYGTTGLRVIDISHWPKELSGPPMASIYAAGEKAADIIKGEHGWLGN