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xit

Gene
xit
Protein
Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
Organism
Drosophila melanogaster
Length
511 amino acids
Function
Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity). Functions in developmental processes such as germband extension, the apical constriction of mesoderm precursor cells and ventral furrow formation in early embryogenesis prior to gastrulation (PubMed:24681004). Involved in the glycosylation and intracellular distribution of shg (E-cadherin) (PubMed:24681004). Function in cell intercalation in the lateral epidermis during germband extension may be due to its effect on shg (PubMed:24681004).
Similarity
Belongs to the ALG6/ALG8 glucosyltransferase family.
Mass
57.945 kDa
Sequence
MKDLFWHLVGIATGLKILLIPAYHSTDFEVHRNWLAITHSLPLNQWYVDATSEWTLDYPPFFAYFEWLLSQVAKYVDPRMLVVDNLNYESKATVYFQRLSVIVTDLVYVLGVRSCLGSLGLGRDTQQFFAASMLLLLNVGLIFVDHIHFQYNGLLFGILLLSIGSLIRQRFLWSAFAFAVLLNFKHIFLYMAPAFGVYLLRFYCLEQASVVSAVGAVVKLLVVGLTPFAVSFGPFWQQLPQVLSRLFPFKRGLTHAYWAPNFWALYNAADKLAAGVLKVQDGGASTTSGLVQEVRHSVLPAITPPVTFALTALFMLPILVKLFRSAKKQSPLVFLRAVVLCGCSSFVFGWHVHEKAILMVLLPLCLLTLVNREDARYAYVLGIAGYFSLFPLLFDADLYIPRYSLYMSYVAMMYGQLYRIFPGFRGFHTLEWLYMLGFMAIPLYEHLLSFLLHLDQRLPFLPLLLTSVYSALGVLYFFGAYYLYALGISWGKVPIASSTSAAAVKRKRKTK