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wisp

Gene
wisp
Protein
Poly(A) RNA polymerase gld-2 homolog B
Organism
Drosophila melanogaster
Length
1373 amino acids
Function
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific maternal RNAs (bcd, Tl, and tor), forming a poly(A) tail, during late oogenesis and early embryogenesis. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Required for localization of mRNAs to both poles of the egg, to recruit or maintain known centrosomal proteins with two types of microtubule organizing centers (MTOCs): the central MTOC that forms between the meiosis II tandem spindles and the centrosomes of the mitotic spindle. Required at the final stage of oogenesis for meiosis I metaphase arrest and for progression beyond this stage.
Similarity
Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.
Mass
151.312 kDa
Sequence
MFSTRISGDMKIFAADVAESSVTATCNTSVQQQQSQQLEFRTRMSAGSPSSKSGQCHLKFGKYNNKTANLLRQVNSCHSSNSSSNTSNNNNEAIKGQQQQPLHYCNSNNSHSWARKKYFGNGNSNNSLLQQQQQPSSFFQRQQQQHQMQMQQEKQATNNNDALMKNQNVVNAHVSDCKSSDSNNNSTSSSNNNSTISSNNNNTSSASNNNTGSSSSCSNRTKPAKWLNENSSSSSSSNNNNISCRNNNTSSIDTKRRNSSAGATAAYYRKSESESGSSEGAAESTETEATRTGGCNSNRTAESSSADGGTQATMGKSQDQEQDQTVKQRPRQQPLSFWKTNYPQTSATQLKDKETVAAVVSAAAVAAAAAAASASEQQQQQQSLSIEHRRNSGYQQHQQHNYYPYYYSQPKQLTIASFLQKEMLPDSTEKSSSNTGGSNMIRSSSNGNSNFSRHQYGHQSTGSGYQQQQQRYRNAQNVYQQYQHQQQHHAQQHTHPHFRRKHSDNGSGINKKMHYSPPGKSGDPADRSASGQQQHHHPHQQQKTIEILASSHFNAMHRRMQGGNNKNGYYQHSYNPMTGEVGSTPTRSEHQNIYNLTYIHVDTEATGEAASAAGSTPVVKPSLLSKPNISITPASSTTPTTVDRALLPAVRSVSAPASGSALPAPANHVRNMFPPPPLAMLGGHGLLSPVTTTTPTKMISCAQLDEAITAAAASGDKLSTSPSYNQAGHYIMPPQQQQQQQLSSHPIPTGTSSHPPPPPPPHMFFHFADGFCNPGQGHQAPPATMWPHSSSPCYPASYGSSCGSGTGAGTSPHNNDGNAGALRPASPALSSSSLGSESQWSGTSNRSRLGHNGHPSISPTPSALGSAQLSPHLAEMRVQHPLHQQHPPSHASHRPHGQMGGHAMSSYVPHRPPPPPHPSISSPNPTPVATGAGGPWYEMILPPDRYLAQARNIEVTVQPEKLICMCKYDNLSAEIWKRFRGAQQTHNKFKLKMRLWRYLYLWMHQPMFERYRICLVGSTITGFGTDSSDIDMCLLPEQGVHPHQHQYHQHHHFHNEKRTEALIILTLFNAVLKDTEVFQDFNLIEARVPILRFKDISNGIEVDLNFNNCVGIKNTYLLQLYAQMDWRTRPLVVIVKLWAQYHDINDAKRMTISSYSLVLMVLHYLQHACVPHVLPCLHSLYPEKFQLGQQDCLDLDLIEPIEPYQALNTQTLGEHLLGFFKYYSTFDFRNFAISIRTGGVLPVSTCRMAKSPKNDVYQWKELNIEEPFDLSNTARSVYDGPTFERVKAVFLISARRLDHTLDLATIFRPIHHVPEHFPQLQQHQQQFEQQLHHPISGQQRSAGGGGDGANPVPSTLNPDAASTFAETTAAHVA