whiB3

Redox-responsive transcriptional regulator WhiB3

102 amino acids

A redox-sensitive transcriptional regulator. Maintains intracellular redox homeostasis by regulating catabolic metabolism and polyketide biosynthesis. Regulates expression of the redox buffer ergothioneine (ERG). In concert with myothiol (MSH), another redox buffer, responds to low pH leading to acid resistance. Senses changes in the intracellular redox state and helps mediate a metabolic switchover to preferred in vivo carbon sources (fatty acids). The apo- but not holo-form probably binds DNA (By similarity). Plays a role in virulence (PubMed:11880648).

Belongs to the WhiB family.

11.612 kDa

MPQPEQLPGPNADIWNWQLQGLCRGMDSSMFFHPDGERGRARTQREQRAKEMCRRCPVIEACRSHALEVGEPYGVWGGLSESERDLLLKGTMGRTRGIRRTA

whiB3

Redox- and pH-responsive transcriptional regulator WhiB3

102 amino acids

A redox-sensitive transcriptional regulator. Maintains intracellular redox homeostasis by regulating catabolic metabolism and polyketide biosynthesis. Regulates expression of the redox buffer ergothioneine (ERG). In concert with myothiol (MSH), another redox buffer, responds to low pH leading to acid resistance. Senses changes in the intracellular redox state and helps mediate a metabolic switchover to preferred in vivo carbon sources (fatty acids). The apo- but not holo-form probably binds DNA (By similarity).

Belongs to the WhiB family.

11.612 kDa

MPQPEQLPGPNADIWNWQLQGLCRGMDSSMFFHPDGERGRARTQREQRAKEMCRRCPVIEACRSHALEVGEPYGVWGGLSESERDLLLKGTMGRTRGIRRTA

whiB3

Redox- and pH-responsive transcriptional regulator WhiB3

102 amino acids

May respond to mycothiol (MSH) redox potential (E-MSH) which decreases at pH 4.5 for up to 72 hours, indicative of cellular reductive stress; deletion of whiB3 leads to a lesser E-MSH at 72 hours, indicative of cellular oxidative stress (PubMed:26637353). Probably via its effects on production of polyketide lipids, regulates host gene expression, leading to blockage of phagosome maturation (PubMed:26637353). Equilibration of extra- and intracytoplasmic pH kills bacteria (PubMed:26637353).

Belongs to the WhiB family.

11.612 kDa

MPQPEQLPGPNADIWNWQLQGLCRGMDSSMFFHPDGERGRARTQREQRAKEMCRRCPVIEACRSHALEVGEPYGVWGGLSESERDLLLKGTMGRTRGIRRTA

whiB3

Redox-responsive transcriptional regulator WhiB3

96 amino acids

A redox-sensitive transcriptional regulator. Maintains intracellular redox homeostasis by regulating catabolic metabolism and polyketide biosynthesis. Regulates expression of the redox buffer ergothioneine (ERG). In concert with myothiol (MSH), another redox buffer, responds to low pH leading to acid resistance. The apo- but not holo-form probably binds DNA (By similarity).

Belongs to the WhiB family.

10.881 kDa

MPQPQQLPGPNADIWDWQMRGLCRGVDSSMFFHPDGERGRARAQREMRAKEMCRSCPVIAQCRSHALAVGEPYGIWGGLSESERELLLKRGIRRSA