Function
Receptor for egr (PubMed:12084706, PubMed:12894227). Involved in induction of apoptosis by triggering JNK signaling (PubMed:12894227). Mediates the tumor suppressor activity of egr which eliminates oncogenic cells from epithelia, thereby maintaining epithelial integrity (PubMed:19289090). Following UV-induced epidermal damage, binds to egr released from apoptotic epidermal cells and plays a role in development of thermal allodynia, a responsiveness to subthreshold thermal stimuli which are not normally perceived as noxious (PubMed:19375319). Together with Moe, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr (PubMed:23544124).
Sequence
MMPPRLPGGHGGAMRSRSSSSGHHLNTTFHKRRRRRQQHHIGGSHISISHGSYLALLLLSTTCSLVATSASSSSSAANTDIAPPDPPPVSQVSIASSSPCAPQHWWDSQRDRCTPCTRCQGEMIPLRPCQLHTDTICGSIYDLKIDWVVLAKTEPNWKERRKSSEYEHFEHNAPLQHLTHEQLQQLHEEAAAAWVLDWQTGVLYVAVLTCLVFFSVAACILIHHMRQWRRMERRLDQDVEELSTKLMAKLAEVQSLDGGTFFIGNADALRGLPASAATTHPATTQSGIFQPQHVLLPEKRGKHQERRILKTLQPGNVYIEESNAGLGGMGVGLGVRGCSGLKG