About Products Protein Database Contact

wdr81

Gene
wdr81
Protein
WD repeat-containing protein 81
Organism
Danio rerio
Length
2065 amino acids
Function
Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. May also be involved in maintenance of normal mitochondrial structure and organization.
Similarity
Belongs to the WD repeat WDR81 family.
Mass
228.484 kDa
Sequence
MEWLAPALERDLGIDQRQTAHSQRPNELVVLVPTRWVMALRNKRVTRCAKYESFSEGEICTLLQRSQMKLPSGWTRVCIQGLRKRKLGYRFARETGCHGEGLSQDSFMTLMQGVSQSNFRNLWHEAYMTHVQPYADSVEQTPVLALDAVRQALQKLFCSNFISTDRVSPSLSPAKEKEKDCPFLSTCSAPKQSTESLCPNVLPAECLLESEEVLYVVFPYTQYTVHDIVTYSPAKLANSNAKILFILYQLLIAMRECHASGLLCGELSLLDIAVDEQLCSRLKISLAHYEKFKEYRDAVPYALQNKVPMSVSTKDNHNNGVSGQLCRNCQDELKSLVLDWVNGQVSNFQYLMELNRLAGRREGDPNYHPVLPWVVDFTVPYGRFRDLKKSKFRLNKGDKQLDFTYEMTKEALAAVSGSGGSNYPPDLGGPVVPGGPGQSDHLHVPHHISDVLSDITYYVYKARQTPKSVLCSHVRSQWEPNEYPASMERIQSWTPDECIPEFYRDPSIFRSIHPDMPDLDVPPWCNSYEEFIAVHRQLLESREVSQQLHHWIDLTFGYKLSGKEAIKAKNVCLHLVDNHTHLTSYGVVQLFDHPHPPRLALYQYAPPEPPHFGRVNVTTWQIPPLETTMDGVDGLVPEATGCESSGWSVVGRDEELEQAIEALDLSGSSSSTSASVSIPVVGSAAGKTSGETIGLVVSPSHGSFPGEATGNVTNTLGSGIRTAMLHRAASVSKKPEASNLEDFKISLPDGFKPLQPLEELEKLNTFLVKGLHSEIEHTMDLGINKKDLRSVPKVPLSFTDLFQRDMQALGVLIAEIFYSSKLRGLRPETHLRDRFQAVLKLCSTNLRDVPLPLHHALDTLLQVHKHCLKTETIIMHPQGLPFLFKYDPICEGLPPPNPWQLLSPIVSPLPFPEYFPTLHKFIFSYHSKMESINNIQGRDIVFNLWQQLETLLKGDITTEGLEILLPFVLSLMSEESTAVYAAWYLFEPVSRVLGPRNASKYLIKPLVGVYENPRCLRGRFYLYTDCFVLQLIVRLGLQVFLSSLLPHVLQVMTGFESCNTAAGTEWEGMKVLRGAAGALDEEEEEYECDDRRSSNATSSGKVGGGSGGGSGGVGVVGDQGLVDYSSGISLNDQVFLNEGEDFQNGFYVNNSASGATTVGTKQQNQSTANKDQDQESLSVGKLSDKSSASEVSIGDRASLKSADSSQDLKQASDGEDGGELEDEEETVEDREITVQRVPSLEMTLSVCTEESEATVATLEGDVMNGIVQEDGEKNMEEEETEHDPLEDSEEKEHKILLDTVCKTVRWLSAKLGPTLTSRFIARNLLRLLTSCYIGLDKHQFMLSVNEENSLECVGSVYEKKPVVGDQTARPVLECLIYIAHLYGEPVLTYQYLPYIGYLVSPPSSCRLNTRKEAGLLGAVVLTQKIIVFLSDTTLMDMLMKINQEVLLPLLDLLTSTKMGFPSGVQTRSAVCLKTLSLMALICLRIGREMVQQHMAETLSRFFQVFSLLQFLQNQIGSAPRREVAECTYLDLRIPDGAELTIELGVLEELQAVFNPEMAYASYIPFYCLIGDSGIRKLVTNHELVWSLAQSYHERASPGSPESNPVGGQRASAVGLSPSMGRQMSRSPFPAPSSTSTPLGGDILPESGTFGSHLVGNRIQVTRDTEACGSPNLSSLETWTHGRPYGSNAPPMSLATTALSSAGPSFSHSSYSWVMGPTPEDSALKQDLPRSSRSLQGNWLAYWQYEIGLNQQDSHFHFHQIRLQSFIGHSGTAKCLAPLAGEDYFLSGSKDKTVRLWPLYNHGDGTREVEPRLTYTEHRKSIFYVGQLEALQEVVSCDGTVHLWDQFTGKNIRCNEPLDGKNPITAVTTMPAPHCSVVFASADSVLRFIDPRKPGLQHEFRLAYSNLSAGLIRCLAVSPGGRTIAAGFSTGFIVLLDARTGLVLRGWPGHEGDILQMKAAEGNLLVSSSSDHTLTVWKDVEHKPLHQYRTPSDPIHAFDLYGAEIVAGTVANKIGVYSILDSTASLAGSTKLSTENFRGTLTSLSVLPTKRLLLLGSDNGAIRLLA

Gene
WDR81
Protein
WD repeat-containing protein 81
Organism
Homo sapiens
Length
1941 amino acids
Function
Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed:26783301). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed:27126989). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (PubMed:28404643). May also be involved in maintenance of normal mitochondrial structure and organization (By similarity).
Similarity
Belongs to the WD repeat WDR81 family.
Mass
211.697 kDa
Sequence
MAQGSGGREGALRTPAGGWHSPPSPDMQELLRSVERDLSIDPRQLAPAPGGTHVVALVPARWLASLRDRRLPLGPCPRAEGLGEAEVRTLLQRSVQRLPAGWTRVEVHGLRKRRLSYPLGGGLPFEDGSCGPETLTRFMQEVAAQNYRNLWRHAYHTYGQPYSHSPAPSAVPALDSVRQALQRVYGCSFLPVGETTQCPSYAREGPCPPRGSPACPSLLRAEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKVLFILFRVLRAMDACHRQGLACGALSLYHIAVDEKLCSELRLDLSAYERPEEDENEEAPVARDEAGIVSQEEQGGQPGQPTGQEELRSLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVVDFTTPHGRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKARRTPRSVLCGHVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIFRSIHPDMPDLDVPAWCSSSQEFVAAHRALLESREVSRDLHHWIDLTFGYKLQGKEAVKEKNVCLHLVDAHTHLASYGVVQLFDQPHPQRLAGAPALAPEPPLIPKLLVQTIQETTGREDFTENPGQLPNGVGRPVLEATPCEASWTRDRPVAGEDDLEQATEALDSISLAGKAGDQLGSSSQASPGLLSFSVASASRPGRRNKAAGADPGEGEEGRILLPEGFNPMQALEELEKTGNFLAKGLGGLLEVPEQPRVQPAVPLQCLLHRDMQALGVLLAEMVFATRVRTLQPDAPLWVRFQAVRGLCTRHPKEVPVSLQPVLDTLLQMSGPEVPMGAERGKLDQLFEYRPVSQGLPPPCPSQLLSPFSSVVPFPPYFPALHRFILLYQARRVEDEAQGRELVFALWQQLGAVLKDITPEGLEILLPFVLSLMSEEHTAVYTAWYLFEPVAKALGPKNANKYLLKPLIGAYESPCQLHGRFYLYTDCFVAQLMVRLGLQAFLTHLLPHVLQVLAGAEASQEESKDLAGAAEEEESGLPGAGPGSCAFGEEIPMDGEPPASSGLGLPDYTSGVSFHDQADLPETEDFQAGLYVTESPQPQEAEAVSLGRLSDKSSTSETSLGEERAPDEGGAPVDKSSLRSGDSSQDLKQSEGSEEEEEEEDSCVVLEEEEGEQEEVTGASELTLSDTVLSMETVVAGGSGGDGEEEEEALPEQSEGKEQKILLDTACKMVRWLSAKLGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSSGESPPLSAGNIYQKRPVLGDIVSGPVLSCLLHIARLYGEPVLTYQYLPYISYLVAPGSASGPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDILPRISHEVLLPVLSFLTSLVTGFPSGAQARTILCVKTISLIALICLRIGQEMVQQHLSEPVATFFQVFSQLHELRQQDLKLDPAGRGEGQLPQVVFSDGQQRPVDPALLDELQKVFTLEMAYTIYVPFSCLLGDIIRKIIPNHELVGELAALYLESISPSSRNPASVEPTMPGTGPEWDPHGGGCPQDDGHSGTFGSVLVGNRIQIPNDSRPENPGPLGPISGVGGGGLGSGSDDNALKQELPRSVHGLSGNWLAYWQYEIGVSQQDAHFHFHQIRLQSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGDGTSETAPRLVYTQHRKSVFFVGQLEAPQHVVSCDGAVHVWDPFTGKTLRTVEPLDSRVPLTAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRLGGGLNPGLVRALAISPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKAVEGSVLVSSSSDHSLTVWKELEQKPTHHYKSASDPIHTFDLYGSEVVTGTVSNKIGVCSLLEPPSQATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGVIRLLA

Gene
Wdr81
Protein
WD repeat-containing protein 81
Organism
Mus musculus
Length
1934 amino acids
Function
Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (By similarity). May also be involved in maintenance of normal mitochondrial structure and organization (PubMed:23595742).
Similarity
Belongs to the WD repeat WDR81 family.
Mass
211.945 kDa
Sequence
MAQGSRRRKVVLTAGSEGWSPSSGPDMEELLRSVERDLNIDARQLALAPGGTHVVALVSTRWLASLRERRLGPCPRAEGLGEAEVRTLLQRSVQRLPPGWTRVEVHGLRKRRLSYPLGGGVPFEEGSCSPETLTRFMQEVAAQNYRNLWRHAYHTYGQPYSHSTAPSALPALDSIRQALQRVYGCTFLPVGESIPCLSNVRDGPCPSRGSPACPSLLRAEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKVLFLLFRVLRAMDACHRQGLACGALSLHHIAVDEKLCSELRLDLSAYEMPSEDENQEGSEEKNGTGIKSEKEGEGRTECPTCQKELRGLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVVDFTTPYGRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGSGEPPHVPHHISDVLSDITYYVYKARRTPRSVLCGHVRAQWEPHEYPATMERMQTWTPDECIPEFYTDPSIFCSIHPDMPDLDVPAWCSSNQEFVAAHRALLESWEVSQDLHHWIDLTFGYKLQGKEAVKEKNVCLHLVDAHTHLTSYGVVQLFDQPHPQRLAGSPALAPEPPLIPRLLVQPIREATGQEDISGQLINGAGRLVVEATPCETGWTRDRPGTGEDDLEQATEALDSISLPGKAGDQPGSSSSQASPGLLSFSAPSGSRPGRRSKAAGLDPGEGEEGKIVLPEGFSPIQALEELEKVGNFLAKGLGSQLEEPEKPHAQPPVHLQSLFHRDMQVLGVLLAEMVFATRVRILQPDAPLWVRFEAVRGLCIRHSKDIPVSLQPVLDTLLQLSGPKSPMVSKKGKLDPLFEYRPVSQGLPPPSPAQLLSPFSSVVPFPPYFPALHKFILLYQARRVEDEVQGRELAFALWQQLGAVLNDITPEGLEILLPFVLSLMSEEHTAVYTAWYLFEPVAKALGPKNANKYLLKPLIGAYESPCRLHGRFYLYTDCFVAQLVVRLGLQAFLTHLLPHVLQVLAGVEASQEEGKGLVGTTEDEESELPVSGPGSCAFGEEIQMDGQPAASSGLGLPDYRSGVSFHDQADLPDTEDFQAGLYVAESPQPQEAEAVSLGQLSDKSSTSEASQGEERGGDDGGAPADKNSVKSGDSSQDLKQSEGSEEEEEEEGCVVLEEDQEDEVTGTSELTLSDTMLSMETVVAPGDGRDREEEEEPLTEQTEGKEQKILLDTACKMVRWLSAKLGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSSDDTPPLNAGNIYQKRPVLGDIVSGPVLSCLLHIAYLYGEPVLTYQYLPYISYLVAPGSNSNPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDILPRISHEVLLPVLGFLTSFVTGFPSGAQARTVLCVKTISLIALICLRIGQEMVQQHLSEPVATFFQVFSHLHELRQQDLPLDPKGCTEGQLPEATFSDGQRRPVDPTLLEELQKVFTLEMAYTIYVPFSCLLGDIIRKIIPNHELVGELAGLYLESMSPSSRNPASMEPTMASAGPEWDPQSGSCLQDDGHSGTFGSVLVGNRIQIPDSQPQSPGPLGSLSGVGSSGGLSNRNEDNALKRELPRSAHGLSGNWLAYWQYEIGVSQQDAHFHFHQIRLQSFPGHTGAVKCVAALSSEDFFLSGSKDRTVRLWPLYNYGDGTNETASRLIYAQHRKSVFYVGQLEAPQYVVSCDGAVHVWDPFTGKTLRTVDPSDSRVPLTAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRLGGGLNPGLVRSLAVSPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKAVEGSVLISSSSDHSLTVWKELEQKPTHHYKSASDPIHTFDLYGSEVVTGTVANKIGVCSLLEPPSQATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGIIRLLA

Gene
Wdr81
Protein
WD repeat-containing protein 81
Organism
Rattus norvegicus
Length
1933 amino acids
Function
Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C. May also be involved in maintenance of normal mitochondrial structure and organization.
Similarity
Belongs to the WD repeat WDR81 family.
Mass
212.26 kDa
Sequence
MAQGSRRRKVVLTAGAEGCSSSSGPDMEELLRCAERDLNIDARQLALAPGGTHVVALVSTRWLASLRERRLGPCPRAEGLGEAEVRTLLQRSVQRLPQGWTRVEVHGLRKRRLSYPLSRVLPFEEGSCSPETLTRFMQEVAAQNYRNLWRHAYHTYGQPYSHSTAPSAIPALDSIRQALQRVYGCTFLPVGESMQCLSNVRDGPSRGSSACPSLLRAEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKVLFILFRVLRAMDACHRQGLACGALSLHHIAVDEKLCSELRLDLSAYEMPSEDENQEVSEEKDRTGVKSEKDGEGRPGCPTCQKELRGLVLDWVHGRVSNFYYLMQLNRLAGRRQGDPNYHPVLPWVVDFTTPYGRFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGSGEPLHVPHHISDVLSDITYYVYKARRTPRSVLCGHVRAQWEPHEYPATMERMQTWTPDECIPEFYTDPSIFCSIHPDMPDLDVPAWCSSNQEFVTAHRALLESWEVSQDLHHWIDLTFGYKLQGKEAVKEKNVCLHLVDAHTHLTSYGVVQLFDQPHPQRLAGAPALAPEPPLIPRLLVQPIQEATGQEDISGQLINGAGRHVVEVTPCESGWTRERPTAGEDDLEQATEALDSISIPGKAGDQPGSSSSQASPGLLPFSAPSGSRPGRRSKATGLDSGEGDEGKIVLPEGFSPIQALEELEKVGNFLARGLGSQLEEPEKPQAQPPVYLQSLFHRDMQVLGVLLAEMVFATRVRILQPDAPLWVRFEAVRGLCTRHSKDIPVSLQPVLDTLLQLSGPKSPLVVKKGKLDPLFEYRPVSQGLPPPSPAQLLSPFSSVVPFPTYFPALHKFILLYQARRVEDEVQGRELVFALWQQLGAVLNEITPEGLEILLPFVLSLMSEEHTAVYTAWYLFEPVAKALGPKNTIKYLLKPLIGAYENPCRLHGRFYLYTDCFVAQLVVRLGLQAFLIHLLPHVLQVLAGVEASQEEGKGLVGTTEDEENELPVPGPGSCAFGEEIQMGGQPAASSGLGLPDYRSGVSFHDQADLPDTEDFQAGLYVAESPQPQEAEAVSLGQLSDKSSTSEASQGEERGGDDGGAPVDKNSVKSGDSSQDLKQSEGSEEEEEEEEGCVVLEEEEQDEVTGTSELTLSDTILSMETVVAPGDGRDREEEEEPLPEQTEGKEQKILLDTACKMVRWLSAKLGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSCDDSPPLNAGNIYQKRPVLGDIVSGPVLSCLLHIAHLYGEPVLTYQYLPYISYLVAPGSNSSPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDILPRISHEVLLPVLSFLTSFVTGFPSGAQARTVLCVKTISLIALICLRIGQEMVQQHLSEPVATFFQVFSHLHELRQQDLQLDLKGCTEGQLPEATFSDGQRRPVDPTLLEELQKVFTLEMAYTIYVPFSCLLGDIIRKIIPNHELVGELAGLYLESMSPSSLRNPASMEPVTPSAGPEWNPQSGSCLQDDGHSGTFGSVLVGNRIQIPDSQPQSSGPLGSISGVGSGGLSSRNEDNALKRELPRSAHGLSGNWLAYWQYEIGVSQQDAHFHFHQIRLQSFPGHTGAVKCVAALSSEDFFLSGSKDRTVRLWPLYNYGDGTSETAPRLIYAQHRKSVFYVGQLEAPQYVVSCDGAVHVWDPFTGKTLRTVDPSDSRVPLTAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRLGGGLNPGLVRSLAVSPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKAVEGSVIVSSSSDHSLTVWKELEQKPTHHYKSASDPIHTFDLYGSEVVTGTVANKIGVCSLLEPPSQATTKLSSENFRGTLTSLALLPTKRHLLLGSDNGIIRLLA