WDR45

WD repeat domain phosphoinositide-interacting protein 4

360 amino acids

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:23435086, PubMed:28561066). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes (PubMed:28561066). Probably recruited to membranes through its PtdIns3P activity (PubMed:28561066).

Belongs to the WD repeat SVP1 family.

39.868 kDa

MTQQPLRGVTSLRFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSMGLVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKEKLVLEFTFTKPVLSVRMRHDKIVIVLKNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF

Wdr45

WD repeat domain phosphoinositide-interacting protein 4

360 amino acids

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Probably recruited to membranes through its PtdIns3P activity.

Belongs to the WD repeat SVP1 family.

39.787 kDa

MTQQPLRGVTSLHFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSVGLVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKDKLVLEFTFTKPVLAVRMRHDKIVIVLRNRIYVYSFPDSPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLASTKPGTSSAPFTINAHQSDVACVSLNQPGTVVASASQKGTLIRLFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDEDF

wdr45

WD repeat domain phosphoinositide-interacting protein 4

358 amino acids

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.

Belongs to the WD repeat SVP1 family.

39.641 kDa

MAQQRGVNSLQFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSIALCSMLHRSNLLAVVGGGVNPKFSEISVLIWDDAREVRDPKDKLVLEFTFTKPVLAVRMRHDKIIIILKNRIYVYSFPDNPVKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVDLSNTKPGTSSAPFTINAHQSEIACLALNQPGSVVASASRKGTLIRLFDTTTRDKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTKLNRRSALARVGKVGPVIGQYVDSQWSLANFTVPAECACICAFGKNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF

wdr45

WD repeat domain phosphoinositide-interacting protein 4

355 amino acids

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation.

Belongs to the WD repeat SVP1 family.

39.234 kDa

MSQQRGVNGLRFNQDQSCFCCAMETGVRIFNIEPLMEKGHLDQEQVGSVGQVEMLHRCNLLALVGGGSNPKFSDISVLIWDDSRDGKDKLVLEFTFTKPVLSVRLRSDKIVIALKNRIYVYSFPDNPTKLFEFDTRDNPKGLCDLCPSLEKQLLIFPGHKCGSLQLVDLCNAKPGSSSAPFTINAHQSELGCLAINQQGTLVASASRKGTLIRLFDTQTREQLVELRRGTDPATLYCINFSHDSSFLCSSSDKGTVHIFALKDTKLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGKNTSKNVNSVIAVCVDGTFHKYVFTPEGNCNREAFDVYLDICDDDIF

Wdr45

WD repeat domain phosphoinositide-interacting protein 4

309 amino acids

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:21802374). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Probably recruited to membranes through its PtdIns3P activity.

Belongs to the WD repeat SVP1 family.

34.587 kDa

MTQQPLRGVTSLHFNQDQSCFCCAMETGVRIYNVEPLMEKGHLDHEQVGSVGLVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKDKLVLEFTFTKPVLAVRMRHDKIVIVLRNRIYVYSFPDNPRKLFEFDTRDNPKGLCDLCPSLEKQLLVFPGHKCGSLQLVSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSALARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHKYVFTPDGNCNREAFDVYLDICDDDDF