wdr11

WD repeat-containing protein 11

1239 amino acids

Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of gli3 and cooperates with the transcription factor emx1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles.

137.139 kDa

MASTMIPYTVNIKLAARTLTGTLNLQNKTAVDWGWQGLIAQGCHSSILIIDPNTAQTIQVLERHKANVVKVKWSRENYHHSLSSPYSLRLASADAAGKIIVWDVVSGMAHCEIQEHSKPIQDMDWLWAQDASRDLLLAVHPPNYIVLWNGDTGTKLWKKSYAENILSFSFDPFEPSNLALLTSEGIVFITDFSHSKPPGSGGKKVYIASPHSSPAHSKPAAAQPTGAKKALNKVKVLITNEKPTAEAVTLNDCLQLSYLPSKRNHMLLLYPREILILDLELSQTVGVVAIERSGVPFIQVIPCAQRDALYCLHENGCITLRVCRSTTPSPNETVTDPEQNSQELVYDLRSQCDAIRVTKTVRPYRVVICPVNENKAVLVVSDGRVMLWELKAHASKSSSNLSSGLPPLYSAVNFCGTPLRQNQKCIPDLSLNSMIGHSLIPGVDSPRPLADQKEVHLKFLLTGLLSGLPLPPFSLRMCPPLTTKNINHYQPLLAVGTSNGSVLVYNLTSGLLHKELSVHSCEVRGIEWISLTSFLSFATSVPNNLGLVRNELQHVDLRTGRCFAFRGERGNDEPAIEMIKVSHLKQYLVVVFRDKPLELWDVRTGTLLREMAKNFPTVTALEWSPSHNLKSLKKKQLAAREAMARQTTLADAEQSSVESSVISLLQDAESKSESSQGISAREHFVFTDTDGQVYHITVEGNTVKDGARIPPDGSMGSIACIAWKGDTLVLGDVDGNLNFWDLKARLSRGVPTHRGWVKKIRFAPGKGNQKLLVMYTDGAEVWDTKEVQMVSSIRVGRNVNYRILDIDWCTSDKVVLASDDGCVRVLEMAMKSASYRMDEQDLTDPVWCPYLLLPRAALTLKAFLLLQPWMDTFTMDITQVDYKEKDEIKGLIQEQLNSLSNDIKSVLQDPNLSLLQRCLLVSRLFGDESDLQFWTVASHYIQAFAQSAQSNESVPEGQAAASHLDICHDILCESSFFQGFQLERVRLQEVKRSSYEHTKKCADQLLLLGQTDRAVQLLLETSADNSSYYCDSLKACLVTTITSSGPSQSTIKLVATNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWTRAAWLAKVRLNAAEGSDVLKRWAEHLCSPQVNQKSKAMLVLLSLGCFQKVGEMLHSMRYFDRAALFIEACLKYGVMETNDDINKLVGAAFVDYAKLLRSIGLKQGAVHWASRAGEAGKQLLEDLSQTEGTGTESSPADDTDNSLVNIE

WDR11

WD repeat-containing protein 11

1224 amino acids

Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (PubMed:29426865).

136.685 kDa

MLPYTVNFKVSARTLTGALNAHNKAAVDWGWQGLIAYGCHSLVVVIDSITAQTLQVLEKHKADVVKVKWARENYHHNIGSPYCLRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWLWNQDASRDLLLAIHPPNYIVLWNADTGTKLWKKSYADNILSFSFDPFDPSHLTLLTSEGIVFISDFSPSKPPSGPGKKVYISSPHSSPAHNKLATATGAKKALNKVKILITQEKPSAEFITLNDCLQLAYLPSKRNHMLLLYPREILILDLEVNQTVGVIAIERTGVPFLQVIPCFQRDGLFCLHENGCITLRVRRSYNNIFTTSNEEPDPDPVQELTYDLRSQCDAIRVTKTVRPFSMVCCPVNENAAALVVSDGRVMIWELKSAVCNRNSRNSSSGVSPLYSPVSFCGIPVGVLQNKLPDLSLDNMIGQSAIAGEEHPRGSILREVHLKFLLTGLLSGLPAPQFAIRMCPPLTTKNIKMYQPLLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLSFATSTPNNMGLVRNELQLVDLPTGRSIAFRGERGNDESAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPSHNLKSLRKKQLATREAMARQTVVSDTELSIVESSVISLLQEAESKSELSQNISAREHFVFTDIDGQVYHLTVEGNSVKDSARIPPDGSMGSITCIAWKGDTLVLGDMDGNLNFWDLKGRVSRGIPTHRSWVRKIRFAPGKGNQKLIAMYNDGAEVWDTKEVQMVSSLRSGRNVTFRILDVDWCTSDKVILASDDGCIRVLEMSMKSACFRMDEQELTEPVWCPYLLVPRASLALKAFLLHQPWNGQYSLDISHVDYPENEEIKNLLQEQLNSLSNDIKKLLLDPEFTLLQRCLLVSRLYGDESELHFWTVAAHYLHSLSQEKSASTTAPKEAAPRDKLSNPLDICYDVLCENAYFQKFQLERVNLQEVKRSTYDHTRKCTDQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVATNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWNRAAWLAKVRLNPEECADVLRRWVDHLCSPQVNQKSKALLVLLSLGCFFSVAETLHSMRYFDRAALFVEACLKYGAFEVTEDTEKLITAIYADYARSLKNLGFKQGAVLFASKAGAAGKDLLNELESPKEEPIEE

Wdr11

WD repeat-containing protein 11

1223 amino acids

Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis (PubMed:29263200). Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production (PubMed:29263200). WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (By similarity).

135.937 kDa

MLPYTVNFKVSARTLTGALNAHNKAAVDWGWQGLIAYGCHSLVVVIDSNTAQTLQVLEKHKADIVKVRWARENYHHNIGSPYCLRLASADVTGKIIVWDVAAGVAQCEIQEHVKPIQDVQWLWNQDASRDLLLAIHPPNYIVLWNADTGTKLWKKSYADNILSFSFDPFDPSHLTLLTSEGIVFISDFSPSKPPSGPGKKVYISSPHSSPAHNKLAAATGAKKALNKVKILITQEKPSADFVALNDCLQLAYLPSKRNHMLLLYPREILILDLEVNQTVGVIAIERTGVPFLQVIPCSQRDGLFCLHENGCITLRVRRSYNSICTTSNDEPDLDPVQELTYDLRSQCDAIRVTKTVRPFSMVCCPVNENAAALIVSDGRVMIWELKSAVCSRNARNSSGVSPLYSPVSFCGIPGGVLQNKLPDLSLDNMIGQSAIAGEEHPKGSILQEVHLKFLLTGLLSGLPSPQFAIRMCPPLTTKNIKTYQPLLAVGTSNGSVLVYHLTSGLLHKELSVHSCEVKGIEWTSLTSFLSFAASTPNNMGLVRNELQLVDLPTGRSTAFRGDRGNDESPIEMIKVSHLKQYLAVVFKDKPLELWDIRTCTLLREMSKSFPAITALEWSPSHNLKSLRKKQLATREAMARQTVVSDAELGAVESSVISLLQEAESKAELSQNISAREHFVFTDNDGQVYHLTVEGNSVKDSARIPPDGSMGSITCIAWKGDTLVLGDMDGNLNFWDLKARVSRGIPTHRSWVRKIRFAPGKGNQKLIAMYNDGAEVWDTKEVQMVSSLRSGRNVTFRILDVDWCTSDKVILASDDGCIRVLEMSMKSTCFRMDEQELVEPVWCPYLLVPRAALALKAFLLHQPWNGRYSLDISHIDYPENEEIKTLLQEQLHALSNDIKKLLLDPDFSLLQRCLLVSRLYGDESELHFWTVAAHYLHSLSQAKSGDTVVTKEGAPKDRLSNPLDICYDVLCENTYFQKFQLERVNLQEVKRSTYDHTRKCTDQLLLLGQTDRAVQLLLETSADNQHYYCDSLKACLVTTVTSSGPSQSTIKLVATNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEWNRAAWLAKVRLNSEECADVLKRWVDHLCSPQVNQKSKALLVLLSLGCFVSVAETLHSMRYFDRAALFVEACLKYGAFEVSEDTEKLIAAIYADYARSLKSLGFRQGAVRFASKAGAAGRDLLNELGSTKEELTES