Protein
WD repeat-containing protein 48 homolog
Organism
Caenorhabditis briggsae
Function
Together with wdr-20, binds to and stimulates the activity of the deubiquitinating enzyme usp-46, leading to deubiquitination and stabilization of the glr-1 glutamate receptor.
Similarity
Belongs to the WD repeat WDR48 family.
Sequence
MSGASNTSQSGSKKKLSFIIRDEQEPLHRSAVSALQYDALHSRLFTGGSDTIIRTWSVPQHKDAFSARGGVRSAGKNSPVQYQSSLERHTDWVTDMVLCGNGKLLVSSSNDTTVKVWSIERDNKHGYLDSLNLHTDYVSCLAYAPLAEKVVSASFDRNIFVYDVNSNFNNFRVLVNNLLGCKNSIYSLATTPNLSHCLFFSPHQQIRMFDPRTNDKPMKMRGHSDNVRALLLNDDGTRALSAGSDGTIRLWDIGMQKNIATGIAHEEGVWTIQVDASFKFVYSGGRDRYVLKSPVNDLSKFQVLFKEEAPVKKLLLSEKENPSSIWVGTWKSDIKRWSLNSANQNSNGGDEEGVSSFSTYYTTCKPRSSSPPPGITAPKHIQRLTDARELQNTPELMISGAPAINKYKILNDKRHVLTSDTEDNVALYDVLAGKKVKEYGKRALENVFEEKSKTVYVPSWFIVDSKSGMLQITLDELDVFSSWLTTKDAGFDDSDKETKVNYGGMMLRSLFERWPPCKLATAEAGESDEVQKATSHYYTLPEHTPFIVCEGNGRPLFRLLVGDAGNEFESGELAQCVPPWVTDMIERNVLPKFNKMPFYLLPHPSTNSKQPKKDRLSATEMLLVKKVMEHVYEKVLGNVDANTVPLNQIHTKIEMYCNDQKLEPETDLRTVKHFYWKQSGELLLYYRPVKN