Protein
UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase
Organism
Pseudomonas aeruginosa (strain ATCC 29260 / BCRC 12902 / CIP 102967 / NCIMB 11965 / PA103)
Function
Bifunctional enzyme that mediates C-3 epimerization of the second intermediate followed by reduction at C-4 during serogroup O11 O-antigen biosynthesis, thus catalyzing the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen.
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Sequence
MKVLVTGANGFVGRNLCAHLAERGGIEVVPFTRESSVGNLPELIRSVDFIFHLAGVNRPEKPEEFKIGNSELTYALCEAVRSNGRAIPLLYTSSIQAEVDNEYGLSKRAAEEHLQVLGEDIGCPVYIFRLPNVFGKWSRPNYNSAVATFCHNIIRDIPIQINNSSAEITLVYIDDVVRTFMKVMDGKLSNAVSLQVEPQYQISVGELAEQLYEFRNSRKSLTTARVGSGLTRALYSTYLSFLPEDSFSYDVPMHSDPRGTFVEMLKTADSGQFSFFTAHPGVTRGGHYHHSKTEKFLVIKGMARFKFRNILTGAFYEICTNGEKAEIVETVPGWTHDITNVGTDDMVVMLWANEVFDRENPDTYACSVGEGA